Document Detail

Serum markers of systemic right ventricular function and exercise performance.
MedLine Citation:
PMID:  18185948     Owner:  NLM     Status:  MEDLINE    
The right ventricle, which faces systemic pressure due to congenital heart disease, often develops premature systolic dysfunction. Cardiac hormones might be useful to identify patients with such systolic dysfunction. This prospective study investigated the relationship of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels with right ventricular ejection fraction (RVEF) and exercise performance in patients with a systemic right ventricle. ANP levels were obtained in 24 patients and BNP levels were obtained in 22 patients with systemic right ventricle. Patients underwent exercise study (n = 22) and cardiovascular magnetic resonance imaging (n = 11) or equilibrium radionuclide angiography (n = 13) to determine RVEF. There were 17 patients with complete transposition and 7 patients with corrected transposition. ANP showed an inverse correlation with RVEF (r2 = 0.63, p < 0.001), a weak but statistically significant inverse correlation with exercise duration (r2 = 0.18, p = 0.047) and no relationship with maximal oxygen consumption (peak V'O2) (r2 = 0.10, p = NS). BNP did not show a relationship with any of the parameters measured. ANP shows a strong inverse correlation with RVEF and a weak correlation with exercise duration in patients with a systemic right ventricle. BNP does not show a significant relationship when compared with either parameter. ANP might be a useful tool for identification of systolic right ventricular dysfunction.
Ruchira Garg; Subha V Raman; Timothy M Hoffman; John Hayes; Curt J Daniels
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-10
Journal Detail:
Title:  Pediatric cardiology     Volume:  29     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-12     Completed Date:  2008-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  641-8     Citation Subset:  IM    
Division of Cardiology, Department of Pediatrics, Columbus Children's Hospital, Columbus, OH 43205, USA.
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MeSH Terms
Atrial Natriuretic Factor / blood*
Biological Markers / blood
Exercise Tolerance*
Heart Defects, Congenital / blood,  complications
Natriuretic Peptide, Brain / blood*
Ventricular Dysfunction, Right / blood*,  etiology
Ventricular Function, Right
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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