Document Detail

Serum markers for prediction of spontaneous preterm delivery in preterm labour.
MedLine Citation:
PMID:  21299551     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Simple, more sensitive markers to predict spontaneous preterm delivery in preterm labour are needed. The aim of this study is to compare the clinical effectiveness of various serum inflammatory markers and cervix length for prediction of spontaneous preterm delivery.
MATERIALS AND METHODS: We retrospectively reviewed medical records of 175 patients hospitalized for preterm labour (102 with preterm delivery and 73 with term delivery). For all study subjects, haematological markers and cervix length were recorded on admission. Because neutrophil to lymphocyte ratio (NLR) showed the potential as a diagnostic marker, we designed a combined marker by dividing cervix length by NLR. The diagnostic and prognostic accuracy of the combined marker was analysed using multivariate analyses.
RESULTS: The levels of combined marker (P < 0·001), neutrophil (P < 0·001), lymphocyte (P = 0·02), NLR (P < 0·001), C-reactive protein (P = 0·016) and the cervix length (P < 0·001) in preterm delivery group were significantly different from those of term delivery group. Compared to cervix length or systemic inflammatory markers alone, combined marker showed higher sensitivity (64·2%) and specificity (88·3%) for prediction of preterm delivery. On Cox multivariate analysis, combined marker positive (< 0·29) and short cervix length (< 1·7 cm) were independent poor prognostic factors and combined marker positive was the most powerful prognostic marker for spontaneous preterm delivery (hazard ratio = 5·60, P < 0·001).
CONCLUSIONS: Combined marker could be used as a simple and sensitive parameter for identifying women at risk of spontaneous preterm delivery.
Min-A Kim; Byung Seok Lee; Yong-Won Park; Kyung Seo
Publication Detail:
Type:  Journal Article     Date:  2011-02-08
Journal Detail:
Title:  European journal of clinical investigation     Volume:  41     ISSN:  1365-2362     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-09     Completed Date:  2011-09-09     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  773-80     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation.
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MeSH Terms
Biological Markers / blood
C-Reactive Protein / analysis
Cervical Length Measurement
Cervix Uteri / pathology
Gestational Age
Infant, Newborn
Infant, Premature
Inflammation Mediators / blood
Kaplan-Meier Estimate
Leukocyte Count
Maternal Age
Pregnancy Outcome
Premature Birth / diagnosis*
Retrospective Studies
Reg. No./Substance:
0/Biological Markers; 0/Inflammation Mediators; 9007-41-4/C-Reactive Protein

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