| Serum markers for prediction of spontaneous preterm delivery in preterm labour. | |
| | |
MedLine Citation:
|
PMID: 21299551 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Eur J Clin Invest 2011 ABSTRACT: Background Simple, more sensitive markers to predict spontaneous preterm delivery in preterm labour are needed. The aim of this study is to compare the clinical effectiveness of various serum inflammatory markers and cervix length for prediction of spontaneous preterm delivery. Materials and methods We retrospectively reviewed medical records of 175 patients hospitalized for preterm labour (102 with preterm delivery and 73 with term delivery). For all study subjects, haematological markers and cervix length were recorded on admission. Because neutrophil to lymphocyte ratio (NLR) showed the potential as a diagnostic marker, we designed a combined marker by dividing cervix length by NLR. The diagnostic and prognostic accuracy of the combined marker was analysed using multivariate analyses. Results The levels of combined marker (P < 0·001), neutrophil (P < 0·001), lymphocyte (P = 0·02), NLR (P < 0·001), C-reactive protein (P = 0·016) and the cervix length (P < 0·001) in preterm delivery group were significantly different from those of term delivery group. Compared to cervix length or systemic inflammatory markers alone, combined marker showed higher sensitivity (64·2%) and specificity (88·3%) for prediction of preterm delivery. On Cox multivariate analysis, combined marker positive (< 0·29) and short cervix length (< 1·7 cm) were independent poor prognostic factors and combined marker positive was the most powerful prognostic marker for spontaneous preterm delivery (hazard ratio = 5·60, P < 0·001). Conclusions Combined marker could be used as a simple and sensitive parameter for identifying women at risk of spontaneous preterm delivery. |
| | |
Authors:
|
Min-A Kim; Byung Seok Lee; Yong-Won Park; Kyung Seo |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-8 |
Journal Detail:
|
Title: European journal of clinical investigation Volume: - ISSN: 1365-2362 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0245331 Medline TA: Eur J Clin Invest Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation. |
Affiliation:
|
Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Modelling the resource implications of managing adults with Fabry disease in Italy.
Next Document: Increased plasma CXCL16 levels in patients with chronic kidney diseases.