| Serum markers of bone turnover are increased by modest weight loss with or without weight-bearing exercise in overweight premenopausal women. | |
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MedLine Citation:
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PMID: 19935856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Weight loss improves metabolic fitness and reduces morbidity and mortality; however, weight reduction also reduces bone mineral density (BMD) and increases bone turnover. Weight-bearing aerobic exercise may preserve bone mass and maintain normal bone turnover during weight reduction. We investigated the impact of weight-bearing and nonweight-bearing exercise on serum markers of bone formation and breakdown during short-term, modest weight loss in overweight premenopausal women. Subjects (n = 36) were assigned to 1 of 3 weight-loss interventions designed to produce a 5% reduction in body weight over 6 weeks: (i) energy restriction only (n = 11; DIET); (ii) energy restriction plus nonweight-bearing exercise (n = 12, CYCLE); or (iii) energy restriction plus weight-bearing exercise (n = 13, RUN). Bone turnover markers were measured in serum collected at baseline and after weight loss. All groups achieved a ~5% reduction in body weight (DIET = 5.2%; CYCLE = 5.0%; RUN = 4.7%). Osteocalcin (OC) and C-terminal telopeptide of type I collagen (CTX) increased with weight loss in all 3 groups (p < 0.05), whereas bone alkaline phosphatase was unaltered by the weight-loss interventions. At baseline, OC and CTX were positively correlated (r = 0.36, p = 0.03), but the strength of this association was diminished (r = 0.30, p = 0.06) after weight loss. Modest weight loss, regardless of method, resulted in a significant increase in both OC and CTX. Low-impact, weight-bearing exercise had no effect on serum markers of bone formation or resorption in premenopausal women during weight loss. Future studies that examine the effects of high-impact, weight-bearing activity on bone turnover and BMD during weight loss are warranted. |
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Authors:
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R Scott Rector; Joanne Loethen; Meghan Ruebel; Tom R Thomas; Pamela S Hinton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Applied physiology, nutrition, and metabolism = Physiologie appliqu??e, nutrition et m??tabolisme Volume: 34 ISSN: 1715-5312 ISO Abbreviation: - Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2010-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264333 Medline TA: Appl Physiol Nutr Metab Country: Canada |
Other Details:
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Languages: eng Pagination: 933-41 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO 65211, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers Bone and Bones / metabolism* Exercise / physiology* Humans Overweight / metabolism* Premenopause Weight Loss / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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