| Serum magnesium aberrations in furosemide (frusemide) treated patients with congestive heart failure: pathophysiological correlates and prognostic evaluation. | |
| | |
MedLine Citation:
|
PMID: 12639869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To determine the prevalence of hypomagnesaemia and hypermagnesaemia, to discern various factors associated with abnormal serum magnesium, and to estimate prognostic significance of serum magnesium aberrations in patients with congestive heart failure. DESIGN: Observational study. SETTING: Medical department of a university hospital (tertiary referral centre). PATIENTS: 404 consecutive patients admitted with congestive heart failure as one of the diagnoses and previously treated with furosemide (frusemide) for at least three months. MAIN OUTCOME MEASURES: Clinical, biochemical, and electrocardiographic variables were analysed with respect to serum magnesium aberrations. Following discharge, mortality rates, including sudden death, were registered. RESULTS: Hypomagnesaemia was found in 50 patients (12.3%) and 20 (4.9%) were hypermagnesaemic. Female sex (p < 0.04), diabetes mellitus (p < 0.006), hypocalcaemia (p = 0.03), hyponatraemia (p < 0.05), malignant disease (p = 0.05), and high fever (p = 0.05) were statistically associated with hypomagnesaemia. Renal failure, severe congestive heart failure, and high dose furosemide treatment (> 80 mg/day) were associated with hypermagnesaemia (p < 0.001, p = 0.05, and p < 0.03, respectively). Hypermagnesaemic patients were older and weighed less. On follow up (median duration 43 months), 169 (41.8%) died, with 22 (13%) sudden deaths. Mortality was highest with hypermagnesaemia, lowest with normomagnesaemia, and intermediate with hypomagnesaemia. After adjustment for renal failure, old age, and severity of congestive heart failure, hypomagnesaemia but not hypermagnesaemia emerged as being significantly associated with shorter survival (p = 0.009). No statistical association was found between sudden death and magnesium concentrations. CONCLUSIONS: While hypermagnesaemia seems to represent a prognostic marker only, hypomagnesaemia appears to have an adverse pathophysiological effect. The subgroup of patients at risk for hypomagnesaemia requires frequent serum magnesium determinations and magnesium replacement for as long as hypomagnesaemia persists. |
| | |
Authors:
|
N Cohen; D Almoznino-Sarafian; R Zaidenstein; I Alon; O Gorelik; M Shteinshnaider; S Chachashvily; Z Averbukh; A Golik; Z Chen-Levy; D Modai |
Related Documents
:
|
8857989 - Magnesium in cardioplegia: is it necessary? 15576019 - Angiographic patency study of an albumin-free recombinant streptokinase formulation in ... 3724239 - Content of magnesium in drinking water and deaths from ischaemic heart disease in white... 389259 - Randomised multicentre trial of early mobilisation after uncomplicated myocardial infar... 2140889 - Acylated plasminogen-streptokinase activator complex: a new approach to thrombolytic th... 6692439 - Intraarterial infusion of low-dose streptokinase after acute thromboembolization of the... 22082679 - Absence of socs3 in the cardiomyocyte increases mortality in a gp130-dependent manner a... 10962119 - Prognostic value of left ventricular hypertrophy and geometry in patients with a first,... 2239659 - Silent myocardial ischemia and infarction in diabetics with peripheral vascular disease... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Heart (British Cardiac Society) Volume: 89 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2003 Apr |
Date Detail:
|
Created Date: 2003-03-17 Completed Date: 2003-04-02 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
|
Languages: eng Pagination: 411-6 Citation Subset: AIM; IM |
Affiliation:
|
Department of Internal Medicine F, Assaf Harofeh Medical Centre, Tel-Aviv University, Zerifin, Israel. internal6@asaf.health.gov.il |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Diuretics / therapeutic use* Female Furosemide / therapeutic use* Heart Failure / blood, drug therapy*, mortality Humans Magnesium / blood* Magnesium Deficiency / blood, complications* Male Prognosis Risk Factors Survival Analysis |
| Chemical | |
Reg. No./Substance:
|
0/Diuretics; 54-31-9/Furosemide; 7439-95-4/Magnesium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Attenuation of hypercapnic carbon dioxide chemosensitivity after postinfarction exercise training: p...
Next Document: Evolution of statin prescribing 1994-2001: a case of agism but not of sexism?