| Serum lipoproteins in rats bearing Morris hepatomas of different degrees of differentiation. | |
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MedLine Citation:
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PMID: 233301 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum lipoproteins were measured by ultracentrifugal means in rats bearing hepatomas of different degrees of malignancy (Morris hepatomas 16, 5123TC and 7777) to determine the effect of these hepatomas on serum lipoprotein levels. Serum lipoprotein patterns were altered, especially in rats bearing hepatomas 16 and 7777, which had elevated high-density lipoproteins. (They were not elevated in serum of rats bearing hepatoma 5123TC). This increase in high-density lipoproteins seems to be specific for chemically induced hepatomas since HDL2 is usually decreased in humans and animals with types of cancer not involving the liver. It appears that hepatomas can synthesize lipoproteins, and the serum levels of the host rats are altered depending on the hepatoma. Different biochemistries appear to be associated with each hepatoma. Cholesterol and fatty acid levels of unfractionated serum and of isolated lipoproteins also indicate abnormal lipid/lipoprotein metabolism associated with these hepatomas. |
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Authors:
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A M Dnistrian; M Barclay; O Terebus-Kekish; F M Archibald; H P Morris |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer biochemistry biophysics Volume: 3 ISSN: 0305-7232 ISO Abbreviation: Cancer Biochem. Biophys. Publication Date: 1979 |
Date Detail:
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Created Date: 1981-02-26 Completed Date: 1981-02-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7506524 Medline TA: Cancer Biochem Biophys Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 81-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Cholesterol / blood Fatty Acids / blood Lipoproteins / blood* Lipoproteins, HDL / blood Lipoproteins, LDL / blood Lipoproteins, VLDL / blood Liver Neoplasms, Experimental / blood* Male Rats |
| Grant Support | |
ID/Acronym/Agency:
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CA-08748/CA/NCI NIH HHS; CA-10729/CA/NCI NIH HHS; CA-16889/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Lipoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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