Document Detail


Serum lipoproteins and apolipoproteins in young normocholesterolaemic, non-diabetic Indian men with myocardial infarction.
MedLine Citation:
PMID:  2041847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A-I and apolipoprotein B were evaluated as potential indicators of the risk of coronary artery disease in young (less than 46 years) normocholesterolaemic, non-diabetic men who had previously sustained a myocardial infarction (n = 50) and in healthy age and sex matched controls (n = 122) with a similar socioeconomic background. Significant differences were observed between patients and controls in the mean concentrations of serum total cholesterol, triglycerides, low density lipoprotein cholesterol, high density lipoprotein cholesterol and apolipoprotein B, as well as in the ratios of total cholesterol to high density lipoprotein cholesterol and apolipoprotein A-I to apolipoprotein B. No significant difference was demonstrated in the concentration of apolipoprotein A-I between the two groups. Stepwise discriminant analysis indicated that apolipoprotein B was the best discriminant between patients and controls. The percentage of exact classification was 74% in patients and 66% in controls. When the patients were compared to a subset of controls (n = 50) matched for age and total cholesterol, significant differences were demonstrated only in the mean concentrations of apolipoprotein B. Discriminant analysis confirmed that the best single discriminating variable was apolipoprotein B. The results therefore indicate that in young normocholesterolaemic, non-diabetic Indian men with myocardial infarction, apolipoprotein B is superior to other lipid parameters studied, as a marker for coronary artery disease.
Authors:
M Sewdarsen; R K Desai; S Vythilingum; N Shah; M C Rajput
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  67     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-07-05     Completed Date:  1991-07-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  159-64     Citation Subset:  IM    
Affiliation:
Department of Medicine, R.K. Khan Hospital, Durban, Natal, South Africa.
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MeSH Terms
Descriptor/Qualifier:
Adult
Apolipoproteins / blood*
Apolipoproteins B / blood
Biological Markers / blood
Cholesterol / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Coronary Disease / etiology
Humans
Lipoproteins / blood*
Male
Myocardial Infarction / blood*
Risk Factors
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Apolipoproteins; 0/Apolipoproteins B; 0/Biological Markers; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoproteins; 0/Triglycerides; 57-88-5/Cholesterol
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