Document Detail

Serum lipoprotein (a) in offspring of patients with premature myocardial infarction.
MedLine Citation:
PMID:  11467239     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To compare serum Lp(a), lipids: TC, TG and lipoproteins: HDL-C and LDL-C levels of offspring with history of paternal myocardial infarction with the serum levels in offspring without paternal history of myocardial infarction. SETTING: Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi. METHODS: Thirty offspring between the ages of 8-25 years with the history of paternal myocardial infarction were randomly selected from population and were matched with offspring having no history of parental myocardial infarction. RESULTS: Offspring of fathers who had a myocardial infarction tended to have a significantly raised level of Lp(a) (p < 0.001) compared with those without parental history. None of the other lipoprotein variables we examined exhibited a significant difference between the two groups of subjects. CONCLUSION: The offspring of fathers with early myocardial infarction have higher mean values of Lp(a) than control subjects suggesting that this lipid variable may strongly predispose to CAD.
S M Shah; K A Karira; Salahuddin; M S Soomro; S Ghafoor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JPMA. The Journal of the Pakistan Medical Association     Volume:  51     ISSN:  0030-9982     ISO Abbreviation:  J Pak Med Assoc     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-07-24     Completed Date:  2001-08-23     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  7501162     Medline TA:  J Pak Med Assoc     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  180-3     Citation Subset:  IM    
Department of Biochemistry, Kyber Medical College, Peshawar.
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MeSH Terms
Genetic Predisposition to Disease / genetics
Lipoprotein(a) / blood*
Myocardial Infarction / blood,  genetics*
Risk Factors
Reg. No./Substance:
Erratum In:
J Pak Med Assoc 2001 Dec;51(12):454

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