| Serum lipocalin-2 as an insulin resistance marker in patients with polycystic ovary syndrome. | |
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MedLine Citation:
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PMID: 20511727 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Our aim was to investigate levels of lipocalin-2 and its relationship with metabolic factors in women with polycystic ovary syndrome (PCOS).MATERIALS/SUBJECTS AND METHODS: In this cross-sectional study, two groups of women were studied: group 1 consisted of women with PCOS (no.=30), and group 2 consisted of control women with normal ovulatory function (no.=30). The circulating levels of free testosterone (T), DHEAS, glucose, insulin, triglycerides (TG), HDL, LDL and lipocalin were measured. Insulin resistance was assessed using the homeostasis model assessment (HOMA-IR). In order to determine a lipocalin value indicating insulin resistance, receiver operating characteristic (ROC) curves were established. RESULTS: Serum lipocalin was significantly higher in PCOS subjects (54.26±15.58 vs 26.09±7.47 ng/ml, p=0.0001).We found a close correlation between lipocalin and insulin, lipocalin and HOMA-IR, lipocalin and T, and lipocalin and DHEAS. A cut-off level of >39.54 ng/ml for serum lipocalin has a predictive value for insulin resistance of 81% sensitivity and 82.1% specificity. CONCLUSION: In our study, lipocalin-2 levels were found to be significantly higher in women with PCOS compared to body mass index-matched controls. Serum lipocalin-2 may prove to be a useful marker for insulin resistance in patients with PCOS. |
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Authors:
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E Cakal; M Ozkaya; Y Engin-Ustun; Y Ustun |
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Publication Detail:
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Type: Journal Article Date: 2010-05-28 |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: 34 ISSN: 1720-8386 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-04-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
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Languages: eng Pagination: 97-100 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey. ermancakal@hotmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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