| Serum lipids, lipoproteins and apolipoproteins A and B in epileptic patients treated with valproic acid, carbamazepine or phenobarbital. | |
| | |
MedLine Citation:
|
PMID: 2048399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Serum lipids, lipoproteins and apolipoproteins A and B were measured in 101 epileptic patients receiving chronic treatment with valproic acid, carbamazepine or phenobarbital and in 75 age- and sex-matched control subjects. In relation to controls, subjects treated with valproic acid showed significantly lower values of total and LDL-cholesterol levels; subjects treated with carbamazepine showed significantly higher values of HDL-cholesterol and apolipoprotein A concentrations and subjects treated with phenobarbital showed significantly higher values of total cholesterol, HDL-cholesterol, apolipoprotein A and apolipoprotein B levels. The total cholesterol/HDL-cholesterol ratio was significantly lower in patients receiving valproic acid or carbamazepine but not in the phenobarbital-treated group. Changes in serum lipids profile did not correlate with drug plasma concentrations nor the duration of the treatment. |
| | |
Authors:
|
E P Calandre; C Rodriquez-Lopez; A Blazquez; D Cano |
Related Documents
:
|
21530799 - All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide pro... 8480679 - Marked increase in plasma high-density-lipoprotein cholesterol after prolonged fasting ... 2897239 - Effects of a new alpha 1-blocker, bunazosin hydrochloride, on plasma lipid components i... 21270369 - Adherence index based on the aha 2006 diet and lifestyle recommendations is associated ... 17144439 - Effects of tomatoes on the lipid profile. 9710659 - Medical nutrition therapy lowers serum cholesterol and saves medication costs in men wi... 19307649 - Metabolism and lactation performance in dairy cows fed a diet containing rumen-protecte... 7735589 - Dietary antioxidant vitamin intake and lung function in the general population. 3080429 - Methionine metabolism in mammals. adaptation to methionine excess. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Acta neurologica Scandinavica Volume: 83 ISSN: 0001-6314 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 1991 Apr |
Date Detail:
|
Created Date: 1991-07-16 Completed Date: 1991-07-16 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 250-3 Citation Subset: IM |
Affiliation:
|
Clinical Pharmacology Department, University Hospital, Granada, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Analysis of Variance Apolipoproteins A / blood Apolipoproteins B / blood Carbamazepine / therapeutic use* Child Child, Preschool Cholesterol, HDL / blood Cholesterol, LDL / blood Cholesterol, VLDL / blood Epilepsy / blood*, drug therapy* Female Humans Lipids / blood* Male Middle Aged Phenobarbital / therapeutic use* Valproic Acid / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Apolipoproteins A; 0/Apolipoproteins B; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Cholesterol, VLDL; 0/Lipids; 298-46-4/Carbamazepine; 50-06-6/Phenobarbital; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term observations on calcium accumulation in postischemic gerbil brain.
Next Document: Outcome following occlusion of the middle cerebral artery.