Document Detail

Serum lipid responses to phytosterol-enriched milk in a moderate hypercholesterolemic population is not affected by apolipoprotein E polymorphism or diameter of low-density lipoprotein particles.
MedLine Citation:
PMID:  21048770     Owner:  NLM     Status:  In-Data-Review    
Background/Objectives:The importance of both low-density lipoprotein cholesterol (LDLc) size and the apolipoprotein E (Apo E) in the atherogenic process is known, but there is little information with regard to the effect of phytosterols (PS) on these parameters. The aim of this study was to evaluate the influence of PS on lipid profile and LDLc size according to Apo E genotype.Subjects/Methods:This was a randomized parallel trial employing 75 mild-hypercholesterolemic subjects and consisting of two 3-month intervention phases. After 3 months of receiving a standard healthy diet, subjects were divided into two intervention groups: a diet group (n=34) and a diet+PS group (n=41) that received 2 g/day of PS. Total cholesterol (TC), triacylglycerols, LDLc, high-density lipoprotein cholesterol (HDLc), non-HDLc, Apo A-I and B-100, LDLc size and Apo E genotype were determined.Results:Patients receiving PS exhibited a significant decrease in TC (5.1%), LDLc (8.1%), non-HDLc (7.4%) and Apo B-100/Apo A-I ratio (7.7%), but these effects did not depend on Apo E genotype. No significant changes were found in lipid profile according to Apo E genotype when patients following dietary recommendations were considered as a whole population or separately. No variations in LDLc size were observed in any of the intervention groups.Conclusion:The results of this study show that Apo E genotype does not have an impact on the lipid response to PS as a cholesterol-lowering agent in mild-hypercholesterolemic patients. Furthermore, the evidence obtained confirms that LDLc particle size is not modified when PS are added to a standard healthy diet.
C Bañuls; M L Martínez-Triguero; A López-Ruiz; C Morillas; M M Jarabo; L Bellod; V M Víctor; M Rocha; A Hernández-Mijares
Publication Detail:
Type:  Journal Article     Date:  2010-11-03
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  65     ISSN:  1476-5640     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  255-61     Citation Subset:  IM    
1] Service of Endocrinology, University Hospital Dr Peset, Valencia, Spain [2] CIBER CB/06/02/0045 Research Group, CIBER Actions in Epidemiology and Public Health, Valencia, Spain.
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