Document Detail


Serum lipid and apolipoprotein levels in patients with psoriasis.
MedLine Citation:
PMID:  8011499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although there have been extensive studies of serum lipid levels in psoriasis, the data are conflicting. In the present study, 38 male psoriatic patients and 40 age-matched male control subjects were studied. In addition, a 75 g oral glucose tolerance test (OGTT) was performed in 28 patients and 28 age-matched control subjects, in order to exclude subjects with abnormal OGTT values from the study. Twenty-two patients and 26 control subjects had normal OGTT values. There was a tendency for psoriatic patients with normal glucose tolerance to have increased triglyceride levels, but this was not statistically significant. Total cholesterol and high-density lipoprotein-cholesterol levels in patients were normal. However, serum apo B (P < 0.005), C-II (P < 0.005) and C-III (P < 0.005) levels in patients were significantly elevated compared with control subjects. When control subjects and patients with abnormal OGTT values were also included, a significant increase in triglyceride and apo E levels, and a significant decrease in the apo A-I level were observed in psoriatic patients. These findings suggest that psoriasis per se is associated with increases in apo B, C-II and C-III levels, but that this does not profoundly affect lipid levels. The abnormal lipoprotein metabolism may be related to the high incidence of atherosclerosis in psoriasis.
Authors:
M Seishima; M Seishima; S Mori; A Noma
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  130     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-28     Completed Date:  1994-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  738-42     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Gifu University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Apolipoproteins / analysis*
Glucose Tolerance Test
Humans
Lipase / metabolism
Lipids / blood*
Lipoprotein Lipase / metabolism
Liver / enzymology
Male
Middle Aged
Psoriasis / blood*,  enzymology
Chemical
Reg. No./Substance:
0/Apolipoproteins; 0/Lipids; EC 3.1.1.3/Lipase; EC 3.1.1.34/Lipoprotein Lipase

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