| Serum lipase after secretin stimulation detects mild pancreatic involvement in cystic fibrosis. | |
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MedLine Citation:
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PMID: 15085023 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The assessment of severe pancreatic insufficiency in cystic fibrosis (CF) is not a diagnostic problem. However, identification of mild cases remains a challenge. The aim of this study was to assess the ability of serum lipase after secretin stimulation to identify mild pancreatic insufficiency in patients with CF. MATERIAL AND METHODS: Thirty patients with CF and pancreatic insufficiency (CF-PI) and 30 patients with CF and pancreatic sufficiency (CF-PS) were studied. Thirty healthy subjects with no known gastrointestinal disease served as controls. In all subjects, fecal fat excretion, fecal elastase-1 (E1) concentration and basal and secretin-stimulated serum lipase concentration were measured. RESULTS: All patients with CF-PI and 3 with CF-PS had abnormally low fecal E1 concentrations. The remaining 27 CF-PS patients and all controls had normal values. Basal and post-stimulation lipase levels were extremely low in patients with CF-PI. Mean basal and poststimulation serum lipase concentrations were significantly higher in CF-PS who had normal fecal E1 concentrations but were still below those of controls (P < 0.001). Among the 27 CF-PS patients with normal fecal elastase, high basal and poststimulation lipase values were found in 6 and 17 patients respectively. CONCLUSION: In patients with CF-PS who have normal fecal elastase-1 concentration, the measurement of basal or secretin-stimulated lipase levels might be helpful in identifying the progression of the destructive process in the pancreas. |
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Authors:
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Jaroslaw Walkowiak; Sanda Nousia-Arvanitakis; Aleksandra Lisowska; Robert Piotrowski; Krystyna Strzykala; Bartosz Bychowiec; Tomasz Songin; Assimina Galli-Tsinopoulou; Dorota Sands; Ifigenia Pidonia; Marian Krawczynski; Andrzej Milanowski; Karl-Heinz Herzig |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pediatric gastroenterology and nutrition Volume: 38 ISSN: 0277-2116 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-15 Completed Date: 2004-12-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 430-5 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Institute of Pediatrics, Karol Marcinkowski University of Medical Sciences, Poznan, Poland. jarwalk@am.poznan.pl |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biological Markers / blood Case-Control Studies Child Cystic Fibrosis / complications* Exocrine Pancreatic Insufficiency / diagnosis*, enzymology, etiology Feces / chemistry, enzymology Female Humans Lipase / blood* Lipids / analysis Male Pancreatic Elastase / analysis Secretin / diagnostic use*, pharmacology Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Lipids; 1393-25-5/Secretin; EC 3.1.1.3/Lipase; EC 3.4.21.36/Pancreatic Elastase |
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