Document Detail


Serum lipase after secretin stimulation detects mild pancreatic involvement in cystic fibrosis.
MedLine Citation:
PMID:  15085023     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The assessment of severe pancreatic insufficiency in cystic fibrosis (CF) is not a diagnostic problem. However, identification of mild cases remains a challenge. The aim of this study was to assess the ability of serum lipase after secretin stimulation to identify mild pancreatic insufficiency in patients with CF. MATERIAL AND METHODS: Thirty patients with CF and pancreatic insufficiency (CF-PI) and 30 patients with CF and pancreatic sufficiency (CF-PS) were studied. Thirty healthy subjects with no known gastrointestinal disease served as controls. In all subjects, fecal fat excretion, fecal elastase-1 (E1) concentration and basal and secretin-stimulated serum lipase concentration were measured. RESULTS: All patients with CF-PI and 3 with CF-PS had abnormally low fecal E1 concentrations. The remaining 27 CF-PS patients and all controls had normal values. Basal and post-stimulation lipase levels were extremely low in patients with CF-PI. Mean basal and poststimulation serum lipase concentrations were significantly higher in CF-PS who had normal fecal E1 concentrations but were still below those of controls (P < 0.001). Among the 27 CF-PS patients with normal fecal elastase, high basal and poststimulation lipase values were found in 6 and 17 patients respectively. CONCLUSION: In patients with CF-PS who have normal fecal elastase-1 concentration, the measurement of basal or secretin-stimulated lipase levels might be helpful in identifying the progression of the destructive process in the pancreas.
Authors:
Jaroslaw Walkowiak; Sanda Nousia-Arvanitakis; Aleksandra Lisowska; Robert Piotrowski; Krystyna Strzykala; Bartosz Bychowiec; Tomasz Songin; Assimina Galli-Tsinopoulou; Dorota Sands; Ifigenia Pidonia; Marian Krawczynski; Andrzej Milanowski; Karl-Heinz Herzig
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  38     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-15     Completed Date:  2004-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  430-5     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, Institute of Pediatrics, Karol Marcinkowski University of Medical Sciences, Poznan, Poland. jarwalk@am.poznan.pl
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biological Markers / blood
Case-Control Studies
Child
Cystic Fibrosis / complications*
Exocrine Pancreatic Insufficiency / diagnosis*,  enzymology,  etiology
Feces / chemistry,  enzymology
Female
Humans
Lipase / blood*
Lipids / analysis
Male
Pancreatic Elastase / analysis
Secretin / diagnostic use*,  pharmacology
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Lipids; 1393-25-5/Secretin; EC 3.1.1.3/Lipase; EC 3.4.21.36/Pancreatic Elastase

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