Document Detail

Serum levels of vaspin, obestatin, and apelin-36 in patients with nonalcoholic fatty liver disease.
MedLine Citation:
PMID:  20580037     Owner:  NLM     Status:  MEDLINE    
The novel adipokines vaspin, obestatin, and apelin-36 are associated with insulin resistance and the components of the metabolic syndrome. We assayed circulating levels of these molecules and examined their association with clinical, biochemical, and histologic phenotypes in patients with nonalcoholic fatty liver disease (NAFLD). Serum levels of vaspin, obestatin, and apelin-36 were assayed by enzyme-linked immunosorbent assay in 91 patients with biopsy-proven NAFLD and 81 controls. We analyzed associations between adipokines and the characteristics of patients with NAFLD using multivariable linear regression models. Univariable analysis showed that concentrations of vaspin and apelin-36 were significantly higher in patients with NAFLD than in controls, whereas no differences in obestatin levels were found. Serum vaspin levels showed a statistically significant association with C-reactive protein (r = 0.378, P < .001) and liver fibrosis scores (r = 0.401, P < .001), whereas apelin-36 levels showed a modest association with homeostasis model assessment of insulin resistance (r = 0.204, P < .01). After stepwise linear regression analysis, serum vaspin levels were the only independent predictor of liver fibrosis scores in patients with NAFLD (β = 0.37, t = 3.99, P < .01). Serum vaspin levels are raised in patients with NAFLD regardless of potential confounders and represent an independent predictor of liver fibrosis scores. These findings support further investigation of this novel adipokine in metabolic liver diseases.
Bilge Aktas; Yusuf Yilmaz; Fatih Eren; Oya Yonal; Ramazan Kurt; Yesim Ozen Alahdab; Cigdem Ataizi Celikel; Osman Ozdogan; Nese Imeryuz; Cem Kalayci; Erol Avsar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-26
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  60     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-05-23     Revised Date:  2011-08-08    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  544-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Internal Medicine, Marmara University School of Medicine, Altunizade, Istanbul 34662, Turkey.
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MeSH Terms
Body Mass Index
C-Reactive Protein / metabolism
Enzyme-Linked Immunosorbent Assay
Fatty Liver / blood,  pathology
Ghrelin / blood*
Insulin Resistance / physiology
Intercellular Signaling Peptides and Proteins / blood*
Liver / pathology
Liver Cirrhosis / pathology
Middle Aged
Serpins / blood*
Reg. No./Substance:
0/APLN protein, human; 0/Ghrelin; 0/Intercellular Signaling Peptides and Proteins; 0/SERPINA12 protein, human; 0/Serpins; 9007-41-4/C-Reactive Protein
Comment In:
Metabolism. 2011 Jul;60(7):e1; author reply e2   [PMID:  21397283 ]

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