| Serum levels of tumor necrosis factor in patients with American cutaneous leishmaniasis. | |
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MedLine Citation:
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PMID: 7670536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to evaluate serum levels of TNF-alpha in patients with either of the three clinical forms of American cutaneous leishmaniasis. The 86 patients examined were classified as having either the localized (LCL: 22 patients), mucocutaneous (MCL: 45 patients), or the rare diffuse (DCL: 19 patients) form of the disease. Our results show a significant increase in the mean level of TNF-alpha in the three groups of patients when compared to controls. MCL patients produce significantly higher levels of TNF-alpha than DCL patients. The proportion of individuals positive for serum TNF-alpha was significantly higher in both MCL and DCL patients than in the controls. No significant differences were found in the level of TNF-alpha when compared between before and after cure of 12 patients with MCL. There were no significant correlations between the level of TNF-alpha and the skin test diameter. The results will be discussed in terms of the pathogenesis of the disease in its different clinical forms. |
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Authors:
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M Castes; D Trujillo; M E Rojas; C T Fernandez; L Araya; M Cabrera; J Blackwell; J Convit |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological research Volume: 26 ISSN: 0716-9760 ISO Abbreviation: Biol. Res. Publication Date: 1993 |
Date Detail:
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Created Date: 1995-10-19 Completed Date: 1995-10-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9308271 Medline TA: Biol Res Country: CHILE |
Other Details:
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Languages: eng Pagination: 233-8 Citation Subset: IM |
Affiliation:
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Instituto de Biomedicina, Escuela J.M. Vargas, Facultad de Medicina, Universidad Central de Venezuela, Caracas. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Animals Antigens, Protozoan / immunology Female Humans Hypersensitivity, Delayed / immunology Leishmania / immunology Leishmaniasis, Cutaneous / blood* Leishmaniasis, Diffuse Cutaneous / blood Leishmaniasis, Mucocutaneous / blood Male Middle Aged Tumor Necrosis Factor-alpha / analysis*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Protozoan; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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