Document Detail


Serum levels of tumor necrosis factor in patients with American cutaneous leishmaniasis.
MedLine Citation:
PMID:  7670536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to evaluate serum levels of TNF-alpha in patients with either of the three clinical forms of American cutaneous leishmaniasis. The 86 patients examined were classified as having either the localized (LCL: 22 patients), mucocutaneous (MCL: 45 patients), or the rare diffuse (DCL: 19 patients) form of the disease. Our results show a significant increase in the mean level of TNF-alpha in the three groups of patients when compared to controls. MCL patients produce significantly higher levels of TNF-alpha than DCL patients. The proportion of individuals positive for serum TNF-alpha was significantly higher in both MCL and DCL patients than in the controls. No significant differences were found in the level of TNF-alpha when compared between before and after cure of 12 patients with MCL. There were no significant correlations between the level of TNF-alpha and the skin test diameter. The results will be discussed in terms of the pathogenesis of the disease in its different clinical forms.
Authors:
M Castes; D Trujillo; M E Rojas; C T Fernandez; L Araya; M Cabrera; J Blackwell; J Convit
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological research     Volume:  26     ISSN:  0716-9760     ISO Abbreviation:  Biol. Res.     Publication Date:  1993  
Date Detail:
Created Date:  1995-10-19     Completed Date:  1995-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9308271     Medline TA:  Biol Res     Country:  CHILE    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  IM    
Affiliation:
Instituto de Biomedicina, Escuela J.M. Vargas, Facultad de Medicina, Universidad Central de Venezuela, Caracas.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Animals
Antigens, Protozoan / immunology
Female
Humans
Hypersensitivity, Delayed / immunology
Leishmania / immunology
Leishmaniasis, Cutaneous / blood*
Leishmaniasis, Diffuse Cutaneous / blood
Leishmaniasis, Mucocutaneous / blood
Male
Middle Aged
Tumor Necrosis Factor-alpha / analysis*,  metabolism
Chemical
Reg. No./Substance:
0/Antigens, Protozoan; 0/Tumor Necrosis Factor-alpha

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