Document Detail

Serum levels of soluble CD95 are not associated with amelioration of multiple sclerosis during pregnancy.
MedLine Citation:
PMID:  17169375     Owner:  NLM     Status:  MEDLINE    
Multiple sclerosis (MS) is considered an autoimmune disease of the central nervous system. Like various other autoimmune disorders, MS normally improves during pregnancy. Pregnant MS patients experience a significant reduction in relapse rates and magnetic resonance (MR) disease activity. How sex steroid hormones affect disease course remains unclear. We hypothesized that hormonal changes during pregnancy might modulate the autoimmune response by enhancing apoptosis of autoreactive T lymphocytes. One of the most important effectors of apoptosis in T cells is the CD95/CD95L system. We have previously reported that the soluble form of CD95 (sCD95) can block CD95-mediated apoptosis and that MS patients show elevated levels of sCD95. Therefore, we considered whether gravidity might influence serum levels of sCD95 in patients, and analyzed the concentration of sCD95 in the sera of 61 patients with relapsing-remitting (RR) MS before, during and after pregnancy. We found no association between serum levels of sCD95 and pregnancy-related immune suppression in MS patients. Thus, sex steroid hormones do not seem to affect the production of anti-apoptotic sCD95.
Stefan Ehrlich; Judith Haas; Frauke Zipp; Carmen Infante-Duarte
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-12
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  252     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-20     Completed Date:  2007-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  83-7     Citation Subset:  IM    
Department of Child and Adolescent Psychiatry, Charité-Universitaetsmedizin Berlin, Germany.
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MeSH Terms
Analysis of Variance
Antigens, CD95 / blood*
Enzyme-Linked Immunosorbent Assay
Fas Ligand Protein / blood
Multiple Sclerosis / blood*
Pregnancy / blood
T-Lymphocytes / metabolism
Reg. No./Substance:
0/Antigens, CD95; 0/Fas Ligand Protein

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