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Serum levels of pro- and anti-inflammatory cytokines in non-pregnant women, during pregnancy, labour and abortion.
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MedLine Citation:
PMID:  9836491     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Disturbance of the cytokine equilibrium has been accused for many pathological disorders. Microbial infections, autoimmune diseases, graft rejection have been correlated to over- or under-production of specific cytokines which are produced as responder molecules to the various immune stimuli. The sole naturally occurring immune reaction in the organism is developed during the gestational period where, despite the presence of a semi-allogeneic graft, maternal immunoreactivity is driven to support fetal growth. The successful embryo development has been attributed to the important intervention of cytokines where some have been characterized as indispensable and others deleterious to fetal growth. However, the physiological levels of many factors during the gestational process have not been determined. Thus, in the present study we have measured and established the values of IL-1alpha, IL-2, IL-3, IL-4, IL-6, IL-10, IL-12, GM-CSF, TNF-alpha and IFN-gamma during all phases of human pregnancy (first, second and third trimester of pregnancy, labour, abortions of the first trimester) as well as in the non-pregnant control state. This is an attempt to assess serum protein concentrations and present the physiological levels of these cytokines at certain time intervals providing thus a diagnostic advantage in pregnancy cases where the mother cannot immunologically support the fetus. Exploitation of this knowledge and further research may be useful for therapeutic interventions in the future.
Authors:
S Vassiliadis; A Ranella; L Papadimitriou; A Makrygiannakis; I Athanassakis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mediators of inflammation     Volume:  7     ISSN:  0962-9351     ISO Abbreviation:  Mediators Inflamm.     Publication Date:  1998  
Date Detail:
Created Date:  1999-01-25     Completed Date:  1999-01-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9209001     Medline TA:  Mediators Inflamm     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  69-72     Citation Subset:  IM    
Affiliation:
Department of Biology, University of Crete, Immunology Centre for Pregnancy, Heraklion, Greece. simon@biology.uch.gr
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / blood
Cytokines / blood*
Female
Humans
Pregnancy / blood*
Pregnancy Trimester, First
Chemical
Reg. No./Substance:
0/Cytokines
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Mediators Inflamm
ISSN: 0962-9351
Article Information
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Print publication date: Year: 1998
Volume: 7 Issue: 2
First Page: 69 Last Page: 72
ID: 1781827
PubMed Id: 9836491

Serum levels of pro- and anti-inflammatory cytokines in non-pregnant women, during pregnancy, labour and abortion.
S Vassiliadis Email: simon@biology.uch.gr
A Ranella
L Papadimitriou
A Makrygiannakis
I Athanassakis
Department of Biology, University of Crete, Immunology Centre for Pregnancy, Heraklion, Greece.


Article Categories:
  • Research Article


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