Document Detail


Serum levels of pigmentation markers are elevated in patients undergoing hemodialysis.
MedLine Citation:
PMID:  18089933     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Diffuse hyperpigmentation is common among patients with chronic renal failure undergoing hemodialysis (HD). We have examined serum levels of 5-S-cysteinyldopa (5SCD, a pheomelanin precursor), pheomelanin, eumelanin, and protein-bound (PB-) 3,4-dihydroxyphenylalanine (DOPA) and PB-5SCD in HD patients. METHODS: Pheomelanin and eumelanin were assayed by chemical degradation methods. RESULTS: Serum levels of free 5SCD in HD patients (n = 16) were 9-fold higher than in healthy controls (n = 16). Levels of pheomelanin in HD patients were 2.6-fold higher than in controls, while levels of eumelanin did not differ between HD patients and controls. Levels of PB-DOPA and PB-5SCD in HD patients were approximately 1.5-fold higher than in controls. Serum levels of free 5SCD were positively correlated to the duration of HD therapy. CONCLUSIONS: The high constitutive levels of free 5SCD, pheomelanin, and PB-DOPA in the blood may be deteriorating in HD patients through the production of reactive oxygen species.
Authors:
Kazutaka Murakami; Kazumasa Wakamatsu; Yukiko Nakanishi; Hiroki Takahashi; Satoshi Sugiyama; Shosuke Ito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-17
Journal Detail:
Title:  Blood purification     Volume:  25     ISSN:  1421-9735     ISO Abbreviation:  Blood Purif.     Publication Date:  2007  
Date Detail:
Created Date:  2008-01-30     Completed Date:  2008-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  483-9     Citation Subset:  IM    
Copyright Information:
2007 S. Karger AG, Basel
Affiliation:
Department of Nephrology, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Cysteinyldopa / blood
Humans
Kidney Failure, Chronic / blood,  therapy
Melanins / blood*
Pigments, Biological / blood*
Reactive Oxygen Species / metabolism
Renal Dialysis / adverse effects*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Melanins; 0/Pigments, Biological; 0/Reactive Oxygen Species; 0/pheomelanin; 12627-86-0/eumelanin; 19641-92-0/Cysteinyldopa
Comments/Corrections
Comment In:
Blood Purif. 2007;25(5-6):480-2   [PMID:  18087150 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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