Document Detail


Serum levels of the osteoprotegerin, receptor activator of nuclear factor kappa-B ligand, metalloproteinase-1 (MMP-1) and tissue inhibitors of MMP-1 levels are increased in men 6 months after acute myocardial infarction.
MedLine Citation:
PMID:  18298349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-B ligand (RANKL) are critical regulators of bone remodeling and RANKL/RANK signaling could also play an important role in the remodeling process of several tissues, such as myocardium. Therefore, we investigated whether the serum concentrations of OPG and RANKL correlate with the serum levels of metalloproteinase-1 (MMP-1), MMP-9 and tissue inhibitors of MMP-1 (TIMP-1), which are known regulators of myocardial healing in acute myocardial infarction (AMI) patients. METHODS: We analyzed blood samples from 51 consecutively hospitalized men with AMI, 12 men with established ischemic heart failure (New York Heart Association category II, NYHA-II) and 12 healthy men age-matched to the NYHA-II patients. Serum levels of MMP-1, MMP-9, TIMP-1, OPG and RANKL were quantified using commercially available ELISA kits. AMI patients were sampled 4 days and 6 months after MI. RESULTS: Our data revealed increased serum levels of OPG, RANKL, MMP-1 and TIMP-1 levels and significant correlations between increased RANKL levels and MMP-1 and TIMP-1 serum levels 6 months after MI. In addition, the ratio OPG/RANKL was very low 6 months after MI, suggesting that the nuclear factor kappa-B signaling is possibly more active 6 months post-MI than it is on day 4 post-MI. CONCLUSIONS: Our data suggest that OPG, RANKL, MMP-1 and TIMP-1 serum levels can be potential mediators of myocardial healing after MI. However, further large studies are needed to confirm the utility of OPG and RANKL as markers of healing after ST elevation in MI.
Authors:
Antonios Halapas; Achilleas Zacharoulis; Stamatios Theocharis; Apostolos Karavidas; Dimitrios Korres; Kostantinos Papadopoulos; Harris Katopodis; Anastasia Stavropoulou; Peter Lembessis; Costas Xiromeritis; Apostolos Zacharoulis; Michael Koutsilieris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry and laboratory medicine : CCLM / FESCC     Volume:  46     ISSN:  1434-6621     ISO Abbreviation:  Clin. Chem. Lab. Med.     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-09     Completed Date:  2008-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9806306     Medline TA:  Clin Chem Lab Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  510-6     Citation Subset:  IM    
Affiliation:
Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Blood Chemical Analysis / methods*
Case-Control Studies
Echocardiography / methods
Gene Expression Regulation*
Humans
Male
Matrix Metalloproteinase 1 / blood*
Middle Aged
Myocardial Infarction / blood*
Osteoprotegerin / blood*
Receptor Activator of Nuclear Factor-kappa B / blood*
Time Factors
Tissue Inhibitor of Metalloproteinase-1 / blood*
Chemical
Reg. No./Substance:
0/Osteoprotegerin; 0/Receptor Activator of Nuclear Factor-kappa B; 0/Tissue Inhibitor of Metalloproteinase-1; EC 3.4.24.7/Matrix Metalloproteinase 1

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