Document Detail


Serum levels of growth arrest specific protein 6 are increased in preeclampsia.
MedLine Citation:
PMID:  23318499     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Preeclampsia (PE) contributes to maternal and fetal morbidity and mortality worldwide. Moreover, it is associated with an increased future metabolic and cardiovascular risk for mother and newborn. Recently, growth arrest specific protein (Gas) 6 has been introduced as a novel metabolic risk factor with anti-angiogenic, pro-atherogenic, and pro-adipogenic properties. In the current study, we investigated serum concentrations of Gas6 in patients with PE (n=51) as compared to healthy, age-matched controls (n=51) during and 6 months after pregnancy. Furthermore, association of Gas6 with markers of renal function, glucose and lipid metabolism, as well as inflammation, was assessed in all individuals. Median maternal Gas6 serum levels adjusted for body mass index and gestational age at blood sampling were significantly increased in PE patients (5.7 μg/l) as compared to healthy, age-matched pregnant women (4.6 μg/l) (p < 0.05). Furthermore, Gas6 concentrations positively correlated with blood pressure, creatinine, free fatty acids, C-reactive protein, leptin, and adiponectin during pregnancy. Moreover, leptin and adiponectin remained independently associated with Gas6 levels in multivariate analysis. Gas6 serum levels 6 months after pregnancy were not significantly different between former PE and control patients. Taken together, maternal Gas6 serum concentrations are significantly increased in PE during pregnancy. Furthermore, the adipokines leptin and adiponectin are independent predictors of circulating Gas6 in pregnant women.
Authors:
Holger Stepan; Judit Richter; Karoline Kley; Susan Kralisch; Alexander Jank; Wiebke Schaarschmidt; Thomas Ebert; Ulrike Lössner; Beate Jessnitzer; Jürgen Kratzsch; Matthias Blüher; Michael Stumvoll; Mathias Fasshauer
Related Documents :
24476649 - Pregnancy in women with glycogen storage disease ia and ib.
20166149 - First-trimester assessment of placenta function and the prediction of preeclampsia and ...
17702049 - Dehydrosteroid measurements in maternal urine or serum for the prenatal diagnosis of sm...
24321039 - Effect of cytochrome p-450 epoxygenase and hydroxylase metabolites on rat myometrium co...
19530579 - The value of mid-trimester routine ultrasonographic screening in antenatal detection of...
14989809 - Prospective study of parental choice for aneuploidy screening in assisted conception ve...
16721579 - Prenatal diagnosis of trisomy 18 as true mosaicism by three-dimensional ultrasonography...
24016619 - Endocrine emergencies in pregnancy.
8878289 - Ultrasound and molecular mid-trimester prenatal diagnosis of de novo achondroplasia.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-11
Journal Detail:
Title:  Regulatory peptides     Volume:  -     ISSN:  1873-1686     ISO Abbreviation:  Regul. Pept.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
University of Leipzig, Department of Obstetrics, 04103 Leipzig, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Intracellular renin alters the electrical properties of the intact heart ventricle of adult Sprague ...
Next Document:  Binding affinities and activation of Asp712Ala and Cys100Ser mutated kinin B(1) receptor forms sugge...