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Serum levels of gelatinase associated lipocalin as indicator of the inflammatory status in coronary artery disease.
MedLine Citation:
PMID:  22988542     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Background. Atherosclerosis is a chronic inflammatory disease and the acute clinical manifestations represent acute on chronic inflammation. Neutrophil gelatinase-associated lipocalin (NGAL) is found in the granules of human neutrophils, with many diverse functions. The aim of this study was to evaluate the hypothesis that levels NGAL in blood may reflect the inflammatory process in various stages of coronary artery disease. Methods. We studied 140 patients, with SA 40, UA 35, NSTEMI 40, and STEMI 25, and 20 healthy controls. Serum NGAL was measured upon admission and before coronary angiography. Results. Significant differences were observed in median serum-NGAL(ng/mL) between patients with SA (79.23 (IQR, 37.50-100.32)), when compared with UA (108.00 (68.34-177.59)), NSTEMI (166.49 (109.24-247.20)), and STEMI (178.63 (111.18-305.92)) patients and controls (50.31 (44.30-69.78)) with significant incremental value from SA to STEMI. We observed a positive and significant correlation between serum-NGAL and hs-CRP (spearman coefficient rho = 0.685, P < 0.0001) as well as with neutrophil counts (r = 0.511, P < 0.0001). Conclusions. In patients with coronary artery disease serum levels of NGAL increase and reflect the degree of inflammatory process. In patients with acute coronary syndromes, serum levels of NGAL have high negative predictive value and reflecting the inflammatory status could show the severity of coronary clinical syndrome.
Authors:
Nikolaos Kafkas; Christos Demponeras; Filitsa Zoubouloglou; Loukia Spanou; Dimitrios Babalis; Konstantinos Makris
Publication Detail:
Type:  Journal Article     Date:  2012-09-04
Journal Detail:
Title:  International journal of inflammation     Volume:  2012     ISSN:  2042-0099     ISO Abbreviation:  Int J Inflam     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-18     Completed Date:  2012-09-19     Revised Date:  2013-04-02    
Medline Journal Info:
Nlm Unique ID:  101538188     Medline TA:  Int J Inflam     Country:  United States    
Other Details:
Languages:  eng     Pagination:  189797     Citation Subset:  -    
Affiliation:
Cardiology Department, KAT General Hospital, Athens, Greece.
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