Document Detail


Serum levels of ficolin-3 (Hakata antigen) in patients with systemic lupus erythematosus.
MedLine Citation:
PMID:  19208603     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Ficolin-3 is a serum protein of putative importance in autoimmunity. Our objective was to investigate any differential expression of ficolin-3 in patients with systemic lupus erythematosus (SLE) or its clinical subsets. METHODS: Serum levels of ficolin-3 (S-ficolin-3) were determined in 95 patients with SLE and 103 healthy controls using an ELISA. RESULTS: Median S-ficolin-3 was 56.1 microg/ml (range 0 to >or=87.3) and 32.4 microg/ml (10 to >or=87.3) in patients and controls, respectively (p<0.001). Increased S-ficolin-3 was associated with hemolysis, positive Coombs test, and lymphopenia, but not with SLE Disease Activity Index scores or C-reactive protein. In one patient without detectable S-ficolin-3, the FCN3 gene appeared normal. CONCLUSION: The elevation of S-ficolin-3 and its association with specific manifestations in SLE may indicate a pathogenetic role of ficolin-3 in SLE.
Authors:
Trine Andersen; Lea Munthe-Fog; Peter Garred; Søren Jacobsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-04
Journal Detail:
Title:  The Journal of rheumatology     Volume:  36     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-03     Completed Date:  2009-06-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  757-9     Citation Subset:  IM    
Affiliation:
Department of Clinical Immunology, University of Copenhagen, and Department of Rheumatology, The University Hospital of Copenhagen, Rigshospitalet, 4242, Blegdamsvej 9, Copenhagen, 2100, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Female
Glycoproteins / blood*,  immunology
Humans
Lectins / blood*,  immunology
Lupus Erythematosus, Systemic / blood*,  immunology,  physiopathology
Male
Middle Aged
Severity of Illness Index
Young Adult
Chemical
Reg. No./Substance:
0/FCN3 protein, human; 0/Glycoproteins; 0/Lectins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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