Document Detail

Serum levels of collagen type-I degradation markers are associated with vascular stiffness in chronic heart failure patients.
MedLine Citation:
PMID:  18849192     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chronic heart failure (CHF) induces peripheral vasoconstriction, endothelial dysfunction and arterial stiffness by activation of various neurohormonal pathways. The abnormal collagen turnover observed in CHF may be attributed not only to myocardial remodelling, but also to vascular remodelling. However, the effect of collagen metabolism on progressive large artery stiffening in the setting of CHF is understudied.
AIMS: The present study was undertaken to investigate the association between circulating markers of collagen turnover and vascular stiffness in patients with CHF.
METHODS: Eighty patients (mean age 65+/-11 years, 68 men) with stable CHF and in sinus rhythm, were studied. Serum concentrations of carboxy-terminal telopeptide of collagen type I (CITP) and amino-terminal propetide of procollagen type I (PINP), markers of collagen type I degregation and synthesis respectively, were measured in all patients. Pulse wave velocity (PWV) and augmentation index (AIx) of aortic pulse wave form, markers of arterial stiffness, were also determined by applanation tonometry.
RESULTS: Peripheral PWV was inversely associated with serum CITP levels (r=-0.585, p<0.001). AIx although weakly was negatively correlated with serum CITP levels (r=-0.285, p=0.01). Multiple regression analysis showed that peripheral PWV remained independently associated with serum CITP levels after adjustment for all confounding variables.
CONCLUSIONS: Findings from the present study imply a possible link between altered collagen metabolism and peripheral vascular stiffness in CHF.
Sofia V Chatzikyriakou; Dimitrios N Tziakas; Georgios K Chalikias; Dimitrios A Stakos; Adina K Thomaidi; Konstantina Mitrousi; Asimina E Lantzouraki; Stamatia Kotsiou; Efstratios Maltezos; Harisios Boudoulas
Publication Detail:
Type:  Journal Article     Date:  2008-10-11
Journal Detail:
Title:  European journal of heart failure     Volume:  10     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-28     Completed Date:  2009-03-11     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1181-5     Citation Subset:  IM    
Department of Cardiology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
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MeSH Terms
Arterial Occlusive Diseases / physiopathology*
Biological Markers / blood
Collagen Type I / blood,  metabolism*
Confidence Intervals
Extracellular Matrix
Heart Failure / blood,  metabolism,  physiopathology*,  ultrasonography
Middle Aged
Models, Statistical
Multivariate Analysis
Peripheral Vascular Diseases / physiopathology*
Risk Factors
Vascular Resistance
Reg. No./Substance:
0/Biological Markers; 0/Collagen Type I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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