| Serum levels of cholesterol and lipoproteins in rhesus monkeys: comparison of the effect of gonadotropin-releasing hormone agonist and the progestin, levonorgestrel. | |
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MedLine Citation:
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PMID: 3106104 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Levonorgestrel, a progestational steroid, and the more widely used antigonadotropin, danazol have been used in the treatment of endometriosis. Both of these agents decrease serum levels of HDL cholesterol. Recently, GnRH agonists came into use for treatment of endometriosis. Our objective in this study was to compare the effects of levonorgestrel and a GnRH analog on serum cholesterol levels in rhesus monkeys being treated for surgically induced endometriosis. A high dose of levonorgestrel significantly reduced total serum cholesterol and HDL cholesterol during a 12-week treatment period. Levonorgestrel had no significant effects on the concentration of LDL/VLDL cholesterol or the percentage of total cholesterol in the HDL fraction. Conversely, the GnRH agonist had no significant effect on total serum cholesterol, HDL cholesterol, LDL/VLDL cholesterol, or the percentage of HDL cholesterol. Because the concentration of HDL cholesterol is closely correlated with atherosclerotic risk, this factor should be weighed in the overall risk/benefit analysis for the patient with endometriosis. |
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Authors:
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R L Schleicher; D R Mann; K G Gould; D C Collins |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Fertility and sterility Volume: 47 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1987 Apr |
Date Detail:
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Created Date: 1987-06-01 Completed Date: 1987-06-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 710-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholesterol / blood* Cholesterol, HDL / blood Cholesterol, LDL / blood Cholesterol, VLDL Endometriosis / drug therapy Female Gonadotropin-Releasing Hormone / analogs & derivatives*, pharmacology, therapeutic use Levonorgestrel Lipoproteins / blood* Lipoproteins, VLDL / blood Macaca mulatta Norgestrel / pharmacology*, therapeutic use Uterine Neoplasms / drug therapy |
| Grant Support | |
ID/Acronym/Agency:
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AMRBAMO-7298-0682/AM/NIADDK NIH HHS; RR00165/RR/NCRR NIH HHS; RR08006/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Cholesterol, VLDL; 0/Lipoproteins; 0/Lipoproteins, VLDL; 33515-09-2/Gonadotropin-Releasing Hormone; 57-88-5/Cholesterol; 6533-00-2/Norgestrel; 66866-63-5/lutrelin acetate; 797-63-7/Levonorgestrel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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