Document Detail


Serum levels of bile salt-stimulated lipase and breast feeding.
MedLine Citation:
PMID:  14714753     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Bile salt-stimulated lipase (BSSL) is present in the sera of healthy humans, may affect lipoprotein structure and composition, and reduce atherogenicity of oxidized LDL-cholesterol. Our aims were to examine serum levels of BSSL in breast- and formula-fed infants, and explore the influence of BSSL on serum lipid profile and oxidative status. METHODS: Infants (2-8 weeks old) were prospectively enrolled. Blood was drawn for serum levels of BSSL, total antioxidant status (TAS), and lipid profile. RESULTS: Serum levels of BSSL were similar in breast-fed (0.28 +/- 0.15 microg/l, n = 18) and formula-fed (0.31 +/- 0.09 microg/l, n = 15) infants, and were much lower than reported levels for adults. In breast-fed infants only, BSSL levels were correlated with LDL-cholesterol serum levels (r = -0.53, p = 0.04). Total cholesterol (119.2 +/- 34.3 mg/dl vs 97 +/- 27.2, and p = 0.05) and LDL-cholesterol serum levels (50.5 +/- 26.1 mg/dl vs 33.3 +/- 20.3, p = 0.05), were elevated in breast-fed compared with formula-fed infants, but TAS was similar in both groups (1.02 +/- 0.18 mmol/l and 0.98 +/- 0.12 mmol/l, respectively). CONCLUSIONS: Lack of difference in BSSL serum levels between formula- and breast-feeding, and lower BSSL levels in infants compared to adults, suggest that human milk does not contribute to BSSL serum levels.
Authors:
Raanan Shamir; Alain Nganga; Drora Berkowitz; Eric Diamond; Sophie Lischinsky; Dominique Lombardo; Naim Shehadeh
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  16     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-12     Completed Date:  2004-08-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  1289-94     Citation Subset:  IM    
Affiliation:
Department of Pediatric Gastroenterology and Nutrition, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion-Institute of Technology, Haifa, Israel. shamirr@netvision.net.il
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / chemistry
Birth Weight / physiology
Breast Feeding*
Cholesterol / chemistry
Cholesterol, HDL / blood,  chemistry
Cholesterol, LDL / blood,  chemistry
Enzyme-Linked Immunosorbent Assay
Female
Humans
Infant
Milk, Human / chemistry,  enzymology
Sterol Esterase / blood*,  chemistry,  pharmacology
Triglycerides / blood,  chemistry
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides; 57-88-5/Cholesterol; EC 3.1.1.-/bile salt-stimulated lipase; EC 3.1.1.13/Sterol Esterase

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