| Serum levels of apelin and ghrelin in patients with acute coronary syndromes and established coronary artery disease--KOZANI STUDY. | |
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MedLine Citation:
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PMID: 20403579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Apelin and ghrelin have emerged as novel adipokines, but their role in coronary artery disease (CAD) remains obscure. In the present study, we analyzed their serum levels in patients with acute coronary syndromes (ACS) or established asymptomatic CAD. A total of 355 participants were enrolled. Among them were 80 patients with unstable angina (UA) and 115 patients with acute myocardial infarction (AMI) hospitalized in the coronary care unit. We also included 88 asymptomatic patients with established CAD (asymptomatic CAD) and 72 age-and sex-matched healthy controls (HCs). All groups with CAD underwent coronary angiography, and the Gensini score was determined. Clinical parameters, glycemic and lipid profile, high-sensitivity CRP (hsCRP), insulin resistance (HOMA-IR), as well as apelin and ghrelin were assayed. Patients with ACS (UA or AMI) were sampled at hospital admission. All 3 groups with CAD (UA, AMI, or asymptomatic CAD) showed significantly higher levels of hsCRP, HOMA-IR, and white blood cells than controls (P < 0.01). Conversely, apelin and ghrelin concentrations were considerably (P < 0.05) lower in CAD patients with respect to the control group. Most importantly, UA (6.72 +/- 3.51 ng/mL) and AMI (6.02 +/- 4.07 ng/mL) groups had even lower apelin levels on admission compared with the asymptomatic CAD group (13.53 +/- 5.2 ng/mL) (P < 0.05). Logistic regression analysis showed an independent association of low apelin and ghrelin levels with CAD presence. Besides this result, apelin showed an inverse relationship with ACS incidence and a Gensini score independent of other cardiovascular risk factors (P < 0.05). In conclusion, CAD seemed to correlate with low serum apelin and ghrelin levels. Moreover, apelin concentrations inversely were associated with the severity and the acute phase of CAD, which suggests its involvement in the progression and destabilization of coronary atherosclerotic plaques. |
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Authors:
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Nikolaos P E Kadoglou; Stilianos Lampropoulos; Alkistis Kapelouzou; Argirios Gkontopoulos; Efstratios K Theofilogiannakos; Grigorios Fotiadis; George Kottas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-21 |
Journal Detail:
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Title: Translational research : the journal of laboratory and clinical medicine Volume: 155 ISSN: 1878-1810 ISO Abbreviation: Transl Res Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-20 Completed Date: 2010-05-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101280339 Medline TA: Transl Res Country: United States |
Other Details:
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Languages: eng Pagination: 238-46 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Mamatsio General Hospital, Kozani, Greece. nikoskad@yahoo.com <nikoskad@yahoo.com> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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blood*,
complications*,
physiopathology Aged Aged, 80 and over Coronary Artery Disease / blood*, complications*, physiopathology Female Ghrelin / blood* Humans Intercellular Signaling Peptides and Proteins / blood* Male Middle Aged Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/APLN protein, human; 0/Ghrelin; 0/Intercellular Signaling Peptides and Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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