Document Detail

Serum levels of apelin and ghrelin in patients with acute coronary syndromes and established coronary artery disease--KOZANI STUDY.
MedLine Citation:
PMID:  20403579     Owner:  NLM     Status:  MEDLINE    
Apelin and ghrelin have emerged as novel adipokines, but their role in coronary artery disease (CAD) remains obscure. In the present study, we analyzed their serum levels in patients with acute coronary syndromes (ACS) or established asymptomatic CAD. A total of 355 participants were enrolled. Among them were 80 patients with unstable angina (UA) and 115 patients with acute myocardial infarction (AMI) hospitalized in the coronary care unit. We also included 88 asymptomatic patients with established CAD (asymptomatic CAD) and 72 age-and sex-matched healthy controls (HCs). All groups with CAD underwent coronary angiography, and the Gensini score was determined. Clinical parameters, glycemic and lipid profile, high-sensitivity CRP (hsCRP), insulin resistance (HOMA-IR), as well as apelin and ghrelin were assayed. Patients with ACS (UA or AMI) were sampled at hospital admission. All 3 groups with CAD (UA, AMI, or asymptomatic CAD) showed significantly higher levels of hsCRP, HOMA-IR, and white blood cells than controls (P < 0.01). Conversely, apelin and ghrelin concentrations were considerably (P < 0.05) lower in CAD patients with respect to the control group. Most importantly, UA (6.72 +/- 3.51 ng/mL) and AMI (6.02 +/- 4.07 ng/mL) groups had even lower apelin levels on admission compared with the asymptomatic CAD group (13.53 +/- 5.2 ng/mL) (P < 0.05). Logistic regression analysis showed an independent association of low apelin and ghrelin levels with CAD presence. Besides this result, apelin showed an inverse relationship with ACS incidence and a Gensini score independent of other cardiovascular risk factors (P < 0.05). In conclusion, CAD seemed to correlate with low serum apelin and ghrelin levels. Moreover, apelin concentrations inversely were associated with the severity and the acute phase of CAD, which suggests its involvement in the progression and destabilization of coronary atherosclerotic plaques.
Nikolaos P E Kadoglou; Stilianos Lampropoulos; Alkistis Kapelouzou; Argirios Gkontopoulos; Efstratios K Theofilogiannakos; Grigorios Fotiadis; George Kottas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-21
Journal Detail:
Title:  Translational research : the journal of laboratory and clinical medicine     Volume:  155     ISSN:  1878-1810     ISO Abbreviation:  Transl Res     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101280339     Medline TA:  Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  238-46     Citation Subset:  AIM; IM    
Department of Cardiology, Mamatsio General Hospital, Kozani, Greece. <>
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MeSH Terms
Acute Coronary Syndrome / blood*,  complications*,  physiopathology
Aged, 80 and over
Coronary Artery Disease / blood*,  complications*,  physiopathology
Ghrelin / blood*
Intercellular Signaling Peptides and Proteins / blood*
Middle Aged
Severity of Illness Index
Reg. No./Substance:
0/APLN protein, human; 0/Ghrelin; 0/Intercellular Signaling Peptides and Proteins

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