Document Detail


Serum levels of VEGF and VEGF-C in patients with endometrial cancer.
MedLine Citation:
PMID:  21411409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endometrial cancer (EC) is the most common type of uterine cancer. A dualistic model of endometrial tumorigenesis serves as a useful way of categorizing these cancers in terms of both etiology and clinical behavior. There are two types of EC: type I and type II. Type I is so-called estrogen-dependent, and appears mostly in pre- and perimenopausal women, it is well differentiated and therefore has a better prognosis. Type II EC is estrogen-independent, diagnosed mostly in postmenopausal women, thin and fertile women, or in women with normal menstrual cycles. It is aggressive and has a worse prognosis than type I. The aim of this study was to evaluate the relationship between the pretreatment serum levels of VEGF and VEGF-C and the outcome of EC patients. A total of 98 patients treated between 1999 and 2003 were included in this study. Circulating VEGF and VEGF-C levels were determined using ELISA kits. VEGF levels among the 76 patients with type I, and the 22 patients with type II EC were significantly higher than those found in the healthy control subjects (p < 0.001). The differences in mean values of VEGF-C were highly significant in both types of tumor examined compared to the control (p < 0.001). The results demonstrate that serum VEGF concentration correlated significantly with advanced FIGO stage in type II EC (p < 0.001). The preoperative VEGF-C level correlated with advancing tumor stages in type I EC (p < 0.05). An elevated preoperative VEGF-C was an independent risk factor for disease-specific survival in patients with type II tumors. Thus, in type II EC patients with high preoperative levels of VEGF-C, pelvic and para-aortic lymphadenectomy should be performed. However, the value of longitudinal measurements of the markers used is yet to be determined.
Authors:
Bozena Dobrzycka; Slawomir J Terlikowski; Oksana Kowalczuk; Marek Kulikowski; Jacek Niklinski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European cytokine network     Volume:  22     ISSN:  1952-4005     ISO Abbreviation:  Eur. Cytokine Netw.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-04     Completed Date:  2011-07-26     Revised Date:  2012-08-31    
Medline Journal Info:
Nlm Unique ID:  9100879     Medline TA:  Eur Cytokine Netw     Country:  France    
Other Details:
Languages:  eng     Pagination:  45-51     Citation Subset:  IM    
Affiliation:
Department of Obstetrics, Gynecology and Obstetrics/Gynecological Care, Medical University of Bialystok, Poland.
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MeSH Terms
Descriptor/Qualifier:
Aged
Endometrial Neoplasms / blood*,  surgery
Female
Humans
Kaplan-Meier Estimate
Middle Aged
Neoplasm Staging
Preoperative Care
Vascular Endothelial Growth Factor A / blood*
Vascular Endothelial Growth Factor C / blood*
Chemical
Reg. No./Substance:
0/VEGFA protein, human; 0/VEGFC protein, human; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factor C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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