| Serum levels of IgG subclasses in relation to IgE and atopic disease in early infancy. | |
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MedLine Citation:
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PMID: 2376023 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The levels of IgG1, IgG2, IgG3, and IgG4 were analysed by ELISA in cord serum and in serum samples collected at 6 and 18 months of age from infants whose mothers were atopic. None of the four IgG subclasses was significantly influenced on any sampling occasion by infant atopy, gender, month of birth, maternal IgE or maternal diet during pregnancy and early lactation. However, at 18 months of age, significantly higher levels of IgG1 (P less than 0.05) and of IgG4 (P less than 0.01) were found in infants with an elevated IgE (greater than or equal to 8.0 kU/l) than in those with a lower level. A weak positive correlation (rs = 0.26; P = 0.05) between IgE and IgG4 was also observed. Despite the fact that the serum levels of IgG4 at 18 months were significantly higher (P less than 0.01) among infants with positive IgE-RAST (greater than or equal to 0.15 PRU/ml) to ovomucoid or beta-lactoglobulin, our data suggest that the the concentration of IgG4 relates more to the level of IgE than to the clinical symptoms of atopy. Determination of IgG subclasses seems to be of limited value for prediciting atopy during early infancy. |
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Authors:
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G Lilja; C G Magnusson; H Oman; S G Johansson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 20 ISSN: 0954-7894 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-09-06 Completed Date: 1990-09-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 407-13 Citation Subset: IM |
Affiliation:
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Sachs Children's Hospital, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Eggs / adverse effects Female Fetal Blood / immunology* Food Hypersensitivity / blood, immunology Humans Hypersensitivity, Immediate / blood*, immunology Immunoglobulin E / analysis* Immunoglobulin G / analysis, classification* Infant Infant Food / adverse effects Infant, Newborn Male Milk / adverse effects Probability Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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