Document Detail

Serum levels of G-CSF, IL-3, IL-6 and GM-CSF after a single intraperitoneal dose of rhG-CSF in lethally irradiated B6D2F1 mice.
MedLine Citation:
PMID:  9352740     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to assess the pharmacokinetics of rhG-CSF after a single intraperitoneal injection 2 h post-TBI in B6D2F1 lethally irradiated mice and to analyze the effect of rhG-CSF on the endogenous response of interleukin-3 (IL-3), interleukin-6 (IL-6) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in these animals. For comparison, these cytokine serum levels have also been measured in nonirradiated mice. The serum concentrations of rhG-CSF in irradiated mice were higher than in nonirradiated mice at all time points during the first 60 min after injection. Furthermore, rhG-CSF administration failed to induce detectable endogenous serum levels of IL-3, IL-6 and GM-CSF, at least in the 72-hour period after administration of the rhG-CSF. The radioprotective effect of rhG-CSF in lethally irradiated mice is not mediated by an increase in endogenous serum levels of these three cytokines.
E Kádár; A Sureda; M A Mangues; J Inglés-Esteve; A Valls; J García
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta haematologica     Volume:  98     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  1997  
Date Detail:
Created Date:  1997-12-05     Completed Date:  1997-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  119-24     Citation Subset:  IM    
Departament de Criobiologia i Teràpia Cellular, Hospital Duran i Reynals, Barcelona, Spain.
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MeSH Terms
Enzyme-Linked Immunosorbent Assay
Granulocyte Colony Stimulating Factor, Recombinant / administration & dosage,  blood,  pharmacokinetics*,  pharmacology
Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology*
Hematopoiesis / radiation effects
Injections, Intraperitoneal
Interleukin-3 / blood*
Interleukin-6 / blood*
Whole-Body Irradiation / adverse effects
Reg. No./Substance:
0/Granulocyte Colony Stimulating Factor, Recombinant; 0/Interleukin-3; 0/Interleukin-6; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

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