| Serum levels of G-CSF, IL-3, IL-6 and GM-CSF after a single intraperitoneal dose of rhG-CSF in lethally irradiated B6D2F1 mice. | |
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MedLine Citation:
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PMID: 9352740 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to assess the pharmacokinetics of rhG-CSF after a single intraperitoneal injection 2 h post-TBI in B6D2F1 lethally irradiated mice and to analyze the effect of rhG-CSF on the endogenous response of interleukin-3 (IL-3), interleukin-6 (IL-6) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in these animals. For comparison, these cytokine serum levels have also been measured in nonirradiated mice. The serum concentrations of rhG-CSF in irradiated mice were higher than in nonirradiated mice at all time points during the first 60 min after injection. Furthermore, rhG-CSF administration failed to induce detectable endogenous serum levels of IL-3, IL-6 and GM-CSF, at least in the 72-hour period after administration of the rhG-CSF. The radioprotective effect of rhG-CSF in lethally irradiated mice is not mediated by an increase in endogenous serum levels of these three cytokines. |
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Authors:
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E Kádár; A Sureda; M A Mangues; J Inglés-Esteve; A Valls; J García |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta haematologica Volume: 98 ISSN: 0001-5792 ISO Abbreviation: Acta Haematol. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-12-05 Completed Date: 1997-12-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 119-24 Citation Subset: IM |
Affiliation:
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Departament de Criobiologia i Teràpia Cellular, Hospital Duran i Reynals, Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Enzyme-Linked Immunosorbent Assay Female Granulocyte Colony Stimulating Factor, Recombinant / administration & dosage, blood, pharmacokinetics*, pharmacology Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology* Hematopoiesis / radiation effects Injections, Intraperitoneal Interleukin-3 / blood* Interleukin-6 / blood* Mice Whole-Body Irradiation / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Granulocyte Colony Stimulating Factor, Recombinant; 0/Interleukin-3; 0/Interleukin-6; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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