Document Detail

Serum levels of ELAM-1, but not CD44, predict the clinical outcome of patients with preeclampsia.
MedLine Citation:
PMID:  10463999     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Preeclampsia is a severe complication in pregnancy, causing considerable maternal and fetal morbidity and mortality. Experimental evidence indicates that adhesion molecules are key factors of endothelial activation in preeclampsia. The aim of our study was to evaluate if serum levels of adhesion molecules CD44 and ELAM-1 provide clinically useful information as prognostic markers for preeclampsia.
METHODS: A matched-pair study including 43 women with preeclampsia and 43 women with uncomplicated pregnancies was performed. Enzyme-linked immunosorbent assay (ELISA) was used to determine serum levels of CD44 and ELAM-1. Results were correlated with clinical data.
RESULTS: Median serum levels of ELAM-1 in controls and in women with preeclampsia were 8.9 ng/mL (minimum 0, maximum 20.0) and 12.0 ng/mL (minimum 4.0, maximum 27.0), respectively (Kruskal-Wallis test, p = 0.01). In a univariate logistic regression model, ELAM-1 did reveal a significant influence on the odds of presenting with preeclampsia as well as on the odds of premature termination of the pregnancy due to preeclampsia (univariate logistic regression, p = 0.03 and p = 0.01, respectively). The risk of premature termination of the pregnancy was 0.5%, 15.3%, and 80.5% at ELAM-1 serum levels of 0 ng/mL, 10 ng/mL, and 20 ng/mL, respectively. No significant correlation between CD44 serum levels and clinicopathological parameters due to preeclampsia was observed.
CONCLUSIONS: If these results are confirmed in a larger series, ELAM-1 could be used as a prognostic factor in preeclamptic women, allowing early identification and appropriate management of high-risk patients with preeclampsia. It is unlikely that measurement of ELAM-1 will be of value as a screening test.
C Tempfer; H Zeisler; L Hefler; C Schatten; P Husslein; C Kainz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  18     ISSN:  1064-1955     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  1999  
Date Detail:
Created Date:  2000-03-20     Completed Date:  2000-03-20     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  45-55     Citation Subset:  IM    
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MeSH Terms
Antigens, CD44 / blood*
Biological Markers / blood
Birth Weight
Cohort Studies
E-Selectin / blood*
Pre-Eclampsia / blood*
Regression Analysis
Reg. No./Substance:
0/Antigens, CD44; 0/Biological Markers; 0/E-Selectin

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