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Serum leptin and total dietary energy intake: the INTERLIPID Study.
MedLine Citation:
PMID:  23224055     Owner:  NLM     Status:  Publisher    
PURPOSE: It has been hypothesized that leptin-induced appetite suppression is impaired in obese individuals, but little human evidence is available documenting this. We investigated relations between serum leptin and total energy intake using INTERLIPID/INTERMAP data on Japanese-Americans in Hawaii and Japanese in Japan. METHODS: Serum leptin and nutrient intakes were examined by standardized methods in men and women aged 40-59 years from two population samples, one Japanese-American in Hawaii (88 men, 94 women), the other Japanese in central Japan (123 men, 111 women). Multiple linear regression analyses stratified by BMI category (<25 kg/m(2), 25-29.9 kg/m(2), and ≥30 kg/m(2)) with adjustment for possible confounders were used to examine the relation between log-leptin and total dietary energy intake. RESULTS: In multivariate regression analyses, in those with BMI < 25 kg/m(2) and in those with BMI between 25 and 29.9 kg/m(2), log-leptin was not significantly related to total dietary energy intake; in those with BMI ≥ 30 kg/m(2), it was significantly inversely related to total dietary energy intake (P = 0.029), independent of body weight and physical activity. Physical activity score was significantly positively related to total dietary energy intake only in participants with BMI < 25 kg/m(2) (P < 0.001). CONCLUSION: Leptin was significantly inversely associated with dietary energy intake in obese persons, but not in overweight and normal-weight persons.
Yasuyuki Nakamura; Hirotsugu Ueshima; Nagako Okuda; Yoshitaka Murakami; Katsuyuki Miura; Yoshikuni Kita; Tomonori Okamura; Akira Okayama; Tanvir C Turin; Sohel R Choudhry; Beatriz Rodriguez; J David Curb; Jeremiah Stamler
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-9
Journal Detail:
Title:  European journal of nutrition     Volume:  -     ISSN:  1436-6215     ISO Abbreviation:  Eur J Nutr     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888704     Medline TA:  Eur J Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Cardiovascular Epidemiology, Kyoto Women's University, 35 Imakumano Kitahiyoshi-cho, Higashiyama-ku, Kyoto, Kyoto, 605-8501, Japan,
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