Document Detail

Serum leptin levels in preterm, healthy and sick-term newborns.
MedLine Citation:
PMID:  12607479     Owner:  NLM     Status:  MEDLINE    
Leptin, a hormone that signals the brain about the status of body (fat) energy stores, has recently been shown to play a role in the regulation of several hypothalamic pituitary axes, including the growth hormone axis. To investigate a potential association of serum leptin concentrations and clinical condition in preterm, sick term and healthy term newborns, serum leptin concentrations were evaluated in 104 newborns. Twenty-eight of them were healthy term (18 males and 10 females; gestational age, 37-42 weeks), 21 were sick term (12 males and 9 females; gestational age, 37-42 weeks) and 55 were preterm neonates (35 males and 20 females; gestational age: 26-37 weeks). Leptin values correlate positively with birth weight, birth length, head circumference, waist circumference, hip circumference, body surface, weight/length ratio, and gestational age (r = 0.38, 0.42, 0.29, 0.21, 0.29, 0.40, 0.31 and 0.28), respectively. The concentrations of leptin are statistically significantly higher (p < 0.05) in term neonates (3.02 +/- 2.94 ng/ml) than preterm neonates (1.93 +/- 2.21 ng/ml). Female infants also have significantly higher (p < 0.05) serum leptin values than male infants in preterm and healthy term groups. We also found leptin present in venous blood after 26 weeks of gestation.
Pen-Hua Su; Shu-Li Wang; Jia-Yuh Chen; Cheng-Pin Chang Lai; Shu-Hua Jian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi     Volume:  43     ISSN:  1608-8115     ISO Abbreviation:  Acta Paediatr Taiwan     Publication Date:    2002 Sep-Oct
Date Detail:
Created Date:  2003-02-27     Completed Date:  2003-03-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100958202     Medline TA:  Acta Paediatr Taiwan     Country:  China (Republic: 1949- )    
Other Details:
Languages:  eng     Pagination:  249-54     Citation Subset:  IM    
Department of Pediatrics, Chung Shan Medical University Hospital, No. 110, Sec. 1, Chien-Kuo North. Road, Taichung 402, Taiwan.
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MeSH Terms
Birth Weight
Body Mass Index
Gestational Age
Infant, Newborn
Infant, Premature
Leptin / blood*
Reg. No./Substance:

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