| Serum leptin levels do not rise during pregnancy in age-matched rats. | |
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MedLine Citation:
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PMID: 9918816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The serum leptin profile and its production in adipose tissue during pregnancy and lactation were investigated along with changes in appetite and factors reflecting nutritional status in 11-week-old rats. Serum leptin levels in pregnant rats were stable except on day 20 of pregnancy and significantly reduced during lactation compared to nonpregnant rats (P < 0.001). Circulating leptin levels corresponded with changes in appetite during pregnancy and postparturition. Leptin mRNA in parametrial adipose tissue reflected the circulating levels, also being significantly reduced during late pregnancy and during lactation (P < 0.05). Leptin mRNA expression was observed in placenta, but the amount suggested little influence on circulating leptin levels. These results indicate that reduction in leptin mRNA in parametrial adipose tissue and circulating leptin levels may increase appetite during late pregnancy and lactation and may play a role in regulating metabolic homeostasis around parturition in rats. |
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Authors:
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Y Terada; K Yamakawa; A Sugaya; N Toyoda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 253 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-02-09 Completed Date: 1999-02-09 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 841-4 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Mie University School of Medicine, Tsu, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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chemistry Age Factors Animals Appetite Blood Glucose / analysis Body Weight Female Insulin / blood Labor, Obstetric / blood* Leptin Male Nutritional Status Pregnancy Pregnancy, Animal / blood* Proteins / analysis*, genetics RNA, Messenger / analysis Rats Rats, Sprague-Dawley Triglycerides / blood Uterus / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Leptin; 0/Proteins; 0/RNA, Messenger; 0/Triglycerides; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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