Document Detail


Serum lecithin: cholesterol acyltransferase activity, HDL2 and HDL3 composition in hypertensive mothers and their small for gestational age newborns.
MedLine Citation:
PMID:  17605041     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to determine serum lecithin:cholesterol acyltransferase (LCAT) activity in parallel with HDL2 and HDL3 amounts and composition in pregnancy induced hypertension (PIH) and chronic hypertensive (CH) mothers and in their small for gestational age (SGA) newborns. LCAT activity was assayed by conversion of [3H] cholesterol to labelled cholesteryl ester. HDL2 and HDL3 were separated by ultracentrifugation. At term, cholesterol values were similar in PIH, CH and controls. However, higher levels of triglycerides were observed in PIH and CH (+20% and +21%, respectively) as compared with normotensive control mothers (NC). HDL2 and HDL3-phospholipids, HDL2-cholesterol concentrations and LCAT activity were lower in PIH and CH mothers than in NC mothers. Similar changes were also observed in SGA newborns of PHI mothers and in SGA newborns of CH mothers when compared to appropriate for gestational age newborns of control mothers (AGA-NC). In addition, SGA newborns showed low HDL2 and HDL3 apoA-I contents. Maternal hypertension and foetal intrauterine growth retardation are associated with profound abnormalities in HDL metabolism, consistent with an atherogenic risk. SGA lipoprotein profiles appear to implicate later metabolic diseases.
Authors:
B Loukidi-Bouchenak; M Y Lamri-Senhadji; S Merzouk; H Merzouk; B Belarbi; J Prost; J Belleville; M Bouchenak
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-29
Journal Detail:
Title:  European journal of pediatrics     Volume:  167     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-03-19     Completed Date:  2008-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  525-32     Citation Subset:  IM    
Affiliation:
Laboratoire de Physiologie Animale et Biochimie,Faculté des Sciences, Université de Tlemcen, Tlemcen, Algeria.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Cholesterol, HDL / blood*
Female
Humans
Hypertension / blood*,  physiopathology
Hypertension, Pregnancy-Induced / blood,  physiopathology
Immunoenzyme Techniques
Incidence
Infant, Newborn
Infant, Small for Gestational Age / blood*
Male
Metabolic Diseases / epidemiology,  etiology*
Phosphatidylcholine-Sterol O-Acyltransferase / blood*
Pregnancy
Prognosis
Risk Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cholesterol, HDL; EC 2.3.1.43/Phosphatidylcholine-Sterol O-Acyltransferase

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