Document Detail


Serum lactoferrin in lepromatous leprosy patients.
MedLine Citation:
PMID:  8127215     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The serum concentrations of lactoferrin were determined by competitive enzyme immunoassay in the sera of 38 lepromatous leprosy patients and 16 healthy volunteers. Of the 38 lepromatous patients, 25 were without any sign of reactions while 13 were suffering from ENL type of reactions. The lactoferrin levels, in both types of patients, were observed to be significantly higher (P < 0.01 and < 0.001, respectively) than in that of healthy volunteers. The rise in lactoferrin level in reactive patients was also higher (P < 0.05) when compared to those without reactions. The serum lactoferrin levels were also found to be associated with bacterial load (r = 0.414; P < 0.01) indicating that in lepromatous leprosy patients, lactoferrin may not be very effective in preventing the growth of Mycobacterium leprae. Further studies to improve the understanding of the role of elevated levels of lactoferrin in pathogenesis of lepromatous leprosy patients and in establishing its possible use in predicting the occurrence of ENL type of reactions would be worthwhile pursuing.
Authors:
O M Parkash; B K Girdhar; U Sengupta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Leprosy review     Volume:  64     ISSN:  0305-7518     ISO Abbreviation:  Lepr Rev     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-04-12     Completed Date:  1994-04-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0243711     Medline TA:  Lepr Rev     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  295-301     Citation Subset:  IM    
Affiliation:
Central JALMA Institute for Leprosy, Tajganj, Agra, India.
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MeSH Terms
Descriptor/Qualifier:
Humans
Lactoferrin / blood*
Leprosy, Lepromatous / blood*
Chemical
Reg. No./Substance:
0/Lactoferrin

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