| Serum kappa and lambda light immunoglobulin chains in cynomolgus macaques (Macaca fascicularis) during the first twenty months of age. | |
MedLine Citation:
|
PMID: 8803610 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Growth is coupled to physiological modifications of the immune system which reaches the functional capabilities according to age-related milestones. Few data are available on the circulating immunoglobulin levels and no data exist on total immunoglobulin light chains in infant macaques. Therefore we studied by a nephelometric assay, the age-dependent variations of kappa and lambda serum light chains in the experimental animal model Macaca fascicularis during the first 20 months of age. Both kappa and lambda showed a marked increase in their concentrations during the first 7-8 months of life. Infants' light chain levels were anyhow significantly lower than those of the nursing dams and of the control group, never attaining, even at the 20th month, the same concentration as the adult, although the value of the kappa/lambda ratio was apparently the same. |
Authors:
|
M Pace; M C D'Ovidio; E Iale; R Strom; P Turillazzi |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Immunology letters Volume: 50 ISSN: 0165-2478 ISO Abbreviation: Immunol. Lett. Publication Date: 1996 May |
Date Detail:
|
Created Date: 1996-11-20 Completed Date: 1996-11-20 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7910006 Medline TA: Immunol Lett Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 139-42 Citation Subset: IM |
Affiliation:
|
Laboratory of Comparative Toxicology and Ecotoxicology, Istituto Superiore di Sanità, Rome, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Animals Animals, Newborn / immunology Female Immunoglobulin kappa-Chains / metabolism* Immunoglobulin lambda-Chains / metabolism* Macaca fascicularis / growth & development, immunology* Male |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulin kappa-Chains; 0/Immunoglobulin lambda-Chains |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phenotypic and functional assessment of intraepithelial lymphocytes (IEL) isolated from rat colon an...
Next Document: The bone marrow peptide (myelopeptide-2) abolishes induced by human leukemia HL-60 cell suppression ...