Document Detail

Serum ischemia modified albumin levels in pregnancies with neural tube defects.
MedLine Citation:
PMID:  22324268     Owner:  NLM     Status:  In-Process    
OBJECTIVE: To evaluate ischemia-modified albumin (IMA) in women who had been pregnant with a child suffering from neural tube defect.
STUDY DESIGN: Samples from 50 women who had been pregnant with an affected child (25 spina bifida, 25 anencephaly) and 25 controls matched for age, gestational age, and body mass index were studied. We measured serum IMA by enzyme-linked immunosorbent assay.
RESULTS: Serum IMA was significantly higher in the study group compared to normal pregnancies (p < 0.05). The area under the receiver operating curve was 0.858 for IMA (95% CI, 0.769-0.947), whereas the optimal threshold value of IMA to discriminate between affected children and controls was 0.409 (sensitivity 88%, specificity 80%). The risk for increased IMA in mothers who have conceived a fetus with neural tube defect is 24.5 times higher than in the control group (rr = 24.5, 6.9-86.9, 95% CI) (p = 0.001).
CONCLUSION: This study indicates that serum IMA in women who have conceived a fetus with neural tube defect is significantly higher than that in normal pregnant women.
Ismail Güzelmansur; Yusuf Ustün; Yaprak Engin-Ustün; Ozlem Oztürk; Halil Yaman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  57     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:    2012 Jan-Feb
Date Detail:
Created Date:  2012-02-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-52     Citation Subset:  IM    
Department of Radiology, Antakya Government Hospital, Ankara, Turkey.
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