Document Detail

Serum ischaemia-modified albumin increases in critical lower limb ischaemia.
MedLine Citation:
PMID:  18499817     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ischaemia is a common phenomenon in the pathogenesis of a wide range of medical and surgical conditions, including myocardial infarction, mesenteric vascular occlusion and compartment syndrome. Ischaemia modified albumin has been suggested as an aid to clinical decision making in various clinical settings. This study examines the usefulness of IMA in the diagnosis of limb ischaemia (LI). METHODS: This case-controlled study was performed in the emergency department of Karadeniz Technical University Hospital, Turkey. 22 patients presenting to the emergency departments and definitively diagnosed with LI were enrolled in the study. A control group of 22 healthy volunteers served as a reference for biochemical parameters. RESULTS: The mean serum IMA level for LI patients was 0.295 (SD 0.062) ABSU. The mean serum IMA level for control patients was 0.174 (SD 0.061) ABSU. There was a statistically significant difference between the mean LI patient and mean control patient IMA levels (p<0.0005). A ROC curve analysis reveals the relationship between sensitivity and specificity for IMA in limb ischaemia. CONCLUSION: There is a significant increase in serum IMA in limb ischaemia. Furthermore, using a cutoff of 0.22 ABSU, ROC curve analysis shows that IMA is 81.8% sensitive and 81.8% specific 81.8% in patients with clinically severe lower limb ischaemia. Future studies would be needed to determine if IMA would be clinically useful in the diagnosis of subtle limb ischaemia.
A Gunduz; A Mentese; S Turedi; S C Karahan; U Mentese; O Eroglu; S Turkmen; I Turan; U Ucar; R Russell; F Balaban
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Emergency medicine journal : EMJ     Volume:  25     ISSN:  1472-0213     ISO Abbreviation:  Emerg Med J     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-23     Completed Date:  2008-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963089     Medline TA:  Emerg Med J     Country:  England    
Other Details:
Languages:  eng     Pagination:  351-3     Citation Subset:  IM    
Department of Emergency Medicine, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.
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MeSH Terms
Aged, 80 and over
Biological Markers / blood
Case-Control Studies
Emergency Service, Hospital
False Positive Reactions
Ischemia / blood,  diagnosis*
Lower Extremity / blood supply*
Middle Aged
Sensitivity and Specificity
Serum Albumin / metabolism*
Reg. No./Substance:
0/Biological Markers; 0/Serum Albumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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