Document Detail

Serum iron levels in schizophrenic patients with or without akathisia.
MedLine Citation:
PMID:  12650948     Owner:  NLM     Status:  MEDLINE    
The pathophysiology of akathisia still remains controversial. Iron deficiency was proposed to be an important factor in the development of akathisia. In the present study, it was aimed to compare levels of serum iron and linked variables in chronic akathisic (n=30), and non-akathisic patients (n=30) with schizophrenia and healthy controls (n=30) because of the controversy in the association of iron and akathisia. The Barnes Akathisia Scale for akathisia and Simpson-Angus Rating Scale for extrapyramidal side effects were used. Serum iron and linked variables and hematological profile of the patients and control subjects were determined. Serum iron levels were significantly lower both in akathisic and non-akathisic groups compared to the control group (P<0.001). Moreover, akathisic patients had significantly lower iron levels than non-akathisic patients (P<0.05). Total iron binding capacity was significantly higher in patients with akathisia compared to the control group (P<0.01). Although non-akathisic patients had a mild increase in total iron binding capacity, it was not statistically significant compared to the control group (P>0.05). Ferritin levels were determined to be significantly lower in both groups compared to the control group (P<0.01). In addition, there was a significant difference in ferritin levels between the patients with and without akathisia (P<0.05). In conclusion, our results support the hypothesis that an association between akathisia and iron metabolism exists.
Murat Kuloglu; Murad Atmaca; Bilal Ustündag; Halit Canatan; Omer Gecici; Ertan Tezcan
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology     Volume:  13     ISSN:  0924-977X     ISO Abbreviation:  Eur Neuropsychopharmacol     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-24     Completed Date:  2003-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111390     Medline TA:  Eur Neuropsychopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  67-71     Citation Subset:  IM    
Department of Psychiatry, College of Medicine and Fýrat Medical Center Fýrat (Euphrates), University Elazig, 23119, Elazig, Turkey.
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MeSH Terms
Akathisia, Drug-Induced / blood*
Antipsychotic Agents / therapeutic use
Iron / blood*
Middle Aged
Patients / statistics & numerical data
Schizophrenia / blood*,  drug therapy
Reg. No./Substance:
0/Antipsychotic Agents; 7439-89-6/Iron

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