Document Detail

Serum interleukin (IL)-1, IL-2, sIL-2Ra, IL-6 and thrombopoietin levels in patients with chronic myeloproliferative diseases.
MedLine Citation:
PMID:  16115126     Owner:  NLM     Status:  MEDLINE    
A number of growth factors are involved in clonal haematopoietic expansion and their clinical significance in patients with chronic myeloproliferative diseases requires further evaluation. Using enzyme-linked immunosorbent assays, we analysed serum levels of interleukin (IL)-1a, IL-1b, IL-2, IL-6, the soluble IL-2 receptor alpha (sIL-2Ra), and thrombopoietin (TPO), in 25 individuals with myelofibrosis with myeloid metaplasia (MMM), 40 with essential thrombocythaemia (ET), eight with polycythaemia vera (PV), 10 patients with chronic myeloid leukaemia (CML) and 27 normal controls. These were correlated with clinicopathological characteristics including overall survival, and histopathological bone marrow features, including angiogenesis. The serum derived from patients with MMM, ET, PV and CML contained significantly higher IL-2 and sIL-2Ra than healthy subjects, while IL-6 levels were higher only in MMM and CML than controls. IL-2, sIL-2Ra and IL-6 levels were raised during the transformation phase of CML, during progression of MMM to AML, and ET and PV to myelofibrosis (P < 0.001). There was a positive correlation between IL-2, sIL-2Ra, IL-6 and angiogenesis in bone marrow samples. Cytokines may be useful markers for predicting clinical evolution, reflecting increased angiogenesis. This requires further evaluation to guide diagnostic and therapeutic options.
Katerina E Panteli; Eleftheria C Hatzimichael; Paraskevi K Bouranta; Afroditi Katsaraki; Konstantinos Seferiadis; Justin Stebbing; Konstantinos L Bourantas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  130     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-23     Completed Date:  2005-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  709-15     Citation Subset:  IM    
Haematology Clinic, University Hospital of Ioannina, Ioannina, Greece.
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MeSH Terms
Aged, 80 and over
Antigens, CD34 / analysis
Biological Markers / analysis,  blood
Bone Marrow / pathology
Bone Marrow Examination
Case-Control Studies
Cytokines / blood*
Enzyme-Linked Immunosorbent Assay / methods
Interleukin-1 / blood
Interleukin-2 / blood
Interleukin-6 / blood
Middle Aged
Myeloproliferative Disorders / blood*,  mortality,  pathology
Neovascularization, Pathologic
Receptors, Interleukin-2 / blood
Statistics, Nonparametric
Survival Rate
Thrombopoietin / blood
Reg. No./Substance:
0/Antigens, CD34; 0/Biological Markers; 0/Cytokines; 0/Interleukin-1; 0/Interleukin-2; 0/Interleukin-6; 0/Receptors, Interleukin-2; 9014-42-0/Thrombopoietin

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