Document Detail


Serum interleukin-6 levels in the steady state of sickle cell disease.
MedLine Citation:
PMID:  8746787     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In patients with childhood sickle cell disease (SCD) serum interleukin-6 (IL-6) levels were measured during the steady (healthy) state of disease. The corresponding measurements were made in comparable healthy normal controls. Serum IL-6 levels were assessed via ELISA in 27 SCD patients and 19 controls. Results revealed significantly higher circulating levels of IL-6 in the SCD patients (60 +/- 7 pg/ml) compared with the healthy controls (12 +/- 5 pg/ml). IL-6 is a multifunctional cytokine that plays a central role in host defense mechanisms. The impact of high circulating levels of IL-6 may be deleterious to humoral and cell-mediated immune functions in SCD, with resultant heightened risk for morbidity.
Authors:
S C Taylor; S J Shacks; R A Mitchell; A Banks
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research     Volume:  15     ISSN:  1079-9907     ISO Abbreviation:  J. Interferon Cytokine Res.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1997-02-12     Completed Date:  1997-02-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9507088     Medline TA:  J Interferon Cytokine Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1061-4     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anemia, Sickle Cell / blood*
Case-Control Studies
Child
Child, Preschool
Evaluation Studies as Topic
Homeostasis
Humans
Infant
Interleukin-6 / blood*
Grant Support
ID/Acronym/Agency:
GM08140-19/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Interleukin-6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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