Document Detail

Serum interleukin-6 correlates with endothelial dysfunction in healthy men independently of insulin sensitivity.
MedLine Citation:
PMID:  17392554     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Interleukin (IL)-6 is a proinflammatory cytokine that is implicated in the pathogenesis of atherosclerosis and insulin resistance. Both endothelial dysfunction and insulin resistance are among the earliest abnormalities that can be detected in people at risk for cardiovascular events. We aimed to evaluate whether increased serum IL-6 concentrations associated with endothelial dysfunction are independent of insulin sensitivity in apparently healthy men. RESEARCH DESIGN AND METHODS: Association studies were performed in well-characterized nondiabetic Caucasian men (n = 99) recruited for energy balance studies. Insulin sensitivity (minimal model) and brachial vascular reactivity (high-resolution external ultrasound) were assessed. Circulating IL-6 concentrations were measured by enzyme-linked immunosorbent assay. RESULTS: Serum IL-6 was an independent contributor to the variance of endothelium-dependent vasodilatation after adjusting for age, BMI, smoking status, LDL cholesterol, systolic blood pressure, diastolic blood pressure, and insulin sensitivity (P = 0.001). In fact, circulating IL-6 was negatively associated with endothelium-dependent vasodilatation (r = -0.247, P = 0.014) and insulin sensitivity (r = -0.262, P = 0.011) and correlated positively with age (r = 0.241, P = 0.016), BMI (r = 0.240, P = 0.017), systolic blood pressure (r = 0.299, P = 0.003), diastolic blood pressure (r = 0.295, P = 0.003), and triglycerides (r = 0.212, P = 0.035). No significant associations were observed between endothelium-independent vasodilatation and serum IL-6 concentrations. CONCLUSIONS: Circulating IL-6 is linked to endothelial dysfunction independently of insulin sensitivity in apparently healthy men.
Eduardo Esteve; Antoni Castro; Abel López-Bermejo; Joan Vendrell; Wifredo Ricart; Jose-Manuel Fernández-Real
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes care     Volume:  30     ISSN:  1935-5548     ISO Abbreviation:  Diabetes Care     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-29     Completed Date:  2007-06-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  939-45     Citation Subset:  IM    
Unit of Diabetes, Endocrinology, and Nutrition, Department of Internal Medicine, Hospital of Girona Dr. Josep Trueta, Girona, Spain.
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MeSH Terms
Biological Markers / blood
Blood Pressure
Body Mass Index
Endothelium, Vascular / physiopathology*
European Continental Ancestry Group
Insulin / blood*
Interleukin-6 / blood*
Lipids / blood
Middle Aged
Reference Values
Regression Analysis
Vasodilation / physiology
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 0/Lipids; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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