Document Detail


Serum interleukin 6 as a predicator of the therapeutic effect and adverse reactions after transcatheter arterial embolization.
MedLine Citation:
PMID:  7780039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the value of serum interleukin 6 (sIL-6) for the prediction of therapeutic effect and adverse reaction after transcatheter arterial embolization (TAE), sIL-6 was measured before and after angiography or TAE in 18 patients (three after angiography and 15 after TAE for hepatocellular carcinoma). The three patients with only angiography showed no elevation of sIL-6, while a significant increase was observed after TAE in the 15 hepatocellular carcinoma patients. The sIL-6 levels of patients with a partial response to TAE were higher at 48-72 hours after the procedure than those of patients with no response (P = 0.045), and the sIL-6 levels of patients who showed adverse reactions were higher at 6-24 h than those of patients without adverse reactions (P = 0.019). sIL-6 level at 48-72 h after TAE reflects the efficacy of TAE, whereas the level at 6-24 h after TAE is related to the severity of adverse reactions. Therefore, sIL-6 may be a useful indicator for prediction of the therapeutic effect of TAE as well as adverse reactions.
Authors:
H Yamazaki; N Nishimoto; H Oi; M Matsushita; A Ogata; Y Shima; T Inoue; J T Tang; K Yoshizaki; T Kishimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cytokine     Volume:  7     ISSN:  1043-4666     ISO Abbreviation:  Cytokine     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-07-18     Completed Date:  1995-07-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  191-5     Citation Subset:  IM    
Affiliation:
Department of Radiation Oncology, Osaka University Medical School, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Angiography / adverse effects
Biological Markers / blood
Carcinoma, Hepatocellular / blood,  therapy*
Embolization, Therapeutic* / adverse effects
Female
Humans
Interleukin-6 / blood*
Liver Neoplasms / blood,  therapy*
Male
Middle Aged
Predictive Value of Tests
Prognosis
Time Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6

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