| Serum interleukin-6 and C-reactive protein are markedly elevated in acute decompensated heart failure patients with left ventricular systolic dysfunction. | |
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MedLine Citation:
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PMID: 20005739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytokines play important roles in heart failure (HF). We examined whether cytokine levels are different in acute decompensated heart failure (ADHF) patients between with left ventricular systolic dysfunction (LVSDF) and with preserved LV ejection function (PLVEF). We studied 81 HF patients who were admitted to our hospital with acute decompensation. They were divided into two groups: LVSDF (LVEF)<45% and PLVEF (LVEF45%). Serum interleukin-6 (IL-6), highly sensitive C-reactive protein (hsCRP), tumor necrosis factor alpha (TNF-alpha), and IL-18 and plasma brain natriuretic peptide (BNP) were measured on admission and at discharge. On admission, IL-6 and hsCRP were higher in LVSDF than in PLVEF. IL-6 and hsCRP decreased after treatment in LVSDF, but not in PLVEF, while plasma BNP levels decreased in both HF with treatment. There was no difference in TNF-alpha or in IL-18 level between LVSDF and PLVEF, and they did not change after treatment in either group. In conclusion, cytokine profiles were different in ADHF between those with LVSDF and PLVEF. Activation of IL-6-hsCRP pathway may play a specific role in ADHF with LVSDF. |
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Authors:
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Mika Matsumoto; Takeshi Tsujino; Masaaki Lee-Kawabata; Yoshiro Naito; Tsuyoshi Sakoda; Mitsumasa Ohyanagi; Tohru Masuyama |
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Publication Detail:
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Type: Journal Article Date: 2009-12-14 |
Journal Detail:
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Title: Cytokine Volume: 49 ISSN: 1096-0023 ISO Abbreviation: Cytokine Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-15 Completed Date: 2010-06-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005353 Medline TA: Cytokine Country: United States |
Other Details:
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Languages: eng Pagination: 264-8 Citation Subset: IM |
Copyright Information:
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2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over C-Reactive Protein / metabolism* Cytokines / blood Female Heart Failure* / blood, physiopathology Humans Interleukin-18 / blood Interleukin-6 / blood* Male Middle Aged Natriuretic Peptide, Brain / blood Tumor Necrosis Factor-alpha / blood Ventricular Dysfunction, Left / blood*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interleukin-18; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 114471-18-0/Natriuretic Peptide, Brain; 9007-41-4/C-Reactive Protein |
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