Document Detail


Serum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis.
MedLine Citation:
PMID:  17302897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interleukin (IL)-18 is a proinflammatory cytokine of the IL-1 superfamily that exhibits broad functional effects in innate and acquired immune responses and which has been found in high levels in several chronic inflammatory and autoimmune diseases. Over-expression of IL-18 may promote early resolution of infection or could promote a detrimental exaggerated immune response. The aim of this study was to determine serum levels of IL-18 and other inflammatory mediators [IL-12, soluble intercellular adhesion molecule 1 (sICAM-1), soluble tumour necrosis factor receptor 1 (TNF-RI), sTNF-RII, CXC chemokine ligand 9 (CXCL9), CXCL10] at baseline and after anti-fungal therapy in serum from patients with juvenile (JF) and adult (AF) forms of paracoccidioidomycosis (PCM), as well as in healthy controls (C), and to assess their possible relationships to the severity of disease. IL-18 and sTNF-RII levels in patients with the JF of PCM were significantly higher than those in the AF and controls. In relation to sICAM-1, no difference was observed between JF and AF patients but both presented higher levels than controls. sTNF-RI levels were higher in patients with PCM than in controls, and significantly higher concentrations were detected in AF patients compared to JF patients. Moreover, IL-12 and chemokines CXCL9 and CXCL10 were also higher in patients than in controls. In JF patients IL-18 levels correlated significantly with sICAM-1 (r=0 x 62, P<0 x 0001), sTNF-RI (r=0 x 63, P<0 x 0001), sTNF-RII (r=0 x 51, P=0 x 02), as well as with clinical severity. The results suggest the value of serum IL-18 and sTNF-Rs levels as a parameter of PCM severity and may support a possible role for them in the pathogenesis of the disease.
Authors:
C L Corvino; R L Mamoni; G Z Z Fagundes; M H S L Blotta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  147     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-16     Completed Date:  2007-05-07     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  483-90     Citation Subset:  IM    
Affiliation:
Department of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), SP, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antibodies, Fungal / blood
Antifungal Agents / therapeutic use
Biological Markers / blood
Chemokines / blood
Child
Female
Humans
Immunoglobulin E / blood
Immunoglobulin G / blood
Inflammation Mediators / blood
Interleukin-18 / blood*
Male
Middle Aged
Paracoccidioides / immunology
Paracoccidioidomycosis / drug therapy,  immunology*
Receptors, Tumor Necrosis Factor, Type II / blood*
Retrospective Studies
Solubility
Chemical
Reg. No./Substance:
0/Antibodies, Fungal; 0/Antifungal Agents; 0/Biological Markers; 0/Chemokines; 0/Immunoglobulin G; 0/Inflammation Mediators; 0/Interleukin-18; 0/Receptors, Tumor Necrosis Factor, Type II; 37341-29-0/Immunoglobulin E
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