Document Detail

Serum interleukin-1 beta in neonatal sepsis.
MedLine Citation:
PMID:  8695999     Owner:  NLM     Status:  MEDLINE    
Serum levels of interleukin-1 beta (IL-1 beta) in newborn infants with septicaemia were measured and possible relationships between the clinical course of the infants, causative micro-organisms and IL-1 beta levels were investigated in a prospective study. The study groups comprised 49 newborn infants (25 mature, 24 premature) with proven sepsis and 40 healthy newborn infants (20 mature, 20 premature). Serum IL-1 beta levels were measured using the IL-1 beta immunoradiometric assay. The levels were found to be lower in neonates with sepsis (median 0.1 pg/ml) than in healthy controls (median 27.9 pg/ml) (p < 0.001). Non-significant trends towards lower levels were observed in children with shock and in non-survivors. No correlation was found between IL-1 beta and postnatal age, gestational age or the study weight of the patients. There was no significant difference in the serum IL-1 beta level in septic patients infected with Gram-positive bacteria and those infected with Gram-negative bacteria. The results show that the concentration of IL-1 beta is significantly decreased in preterm and term neonates with sepsis.
A Atici; M Satar; N Alparslan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  85     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-09-03     Completed Date:  1996-09-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  371-4     Citation Subset:  IM    
Department of Paediatrics, Cukurova University Medical Faculty, Adana, Turkey.
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MeSH Terms
Immunoradiometric Assay
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / blood*
Interleukin-1 / blood*
Prospective Studies
Sepsis / blood*,  microbiology
Reg. No./Substance:

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