| Serum insulin-like system alterations in patients with spinocerebellar ataxia type 3. | |
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MedLine Citation:
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PMID: 21069863 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Spinocerebellar ataxias (SCAs) constitute a group of autosomal dominant neurodegenerative disorders with no current treatment. The insulin/insulin-like growth factor 1 (IGF-1) system (IIS) has been shown to play a role in the neurological dysfunction of SCAs and other polyglutamine disorders. We aimed to study the biomarker profile of serum IIS components in SCA3. We performed a case-control study with 46 SCA3 patients and 42 healthy individuals evaluating the peripheral IIS profile (insulin, IGF-1, IGFBP1 and 3) and the correlation with clinical, molecular, and neuroimaging findings. SCA3 patients presented lower insulin and IGFBP3 levels and higher insulin sensitivity (HOMA2), free IGF-I, and IGFBP1 levels when compared with controls. IGFBP-1 levels were directly associated with CAG expanded repeat length; IGF-1 was associated with the volumetries of specific brainstem regions on magnetic resonance imaging (MRI). Insulin levels and sensitivity were related to age at onset of symptoms. Our findings indicate an involvement of IIS components in SCA3 neurobiology and IGFBP-1 as a potential biomarker of the disease. © 2010 Movement Disorder Society. |
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Authors:
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Jonas Alex Morales Saute; Andrew Chaves Feitosa da Silva; Alexandre Pastoris Muller; Gisele Hansel; Alexandre Silva de Mello; Fábio Maeda; Leonardo Vedolin; Maria Luiza Saraiva-Pereira; Diogo Onofre Souza; Javier Arpa; Ignacio Torres-Aleman; Luis Valmor Cruz Portela; Laura Bannach Jardim |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-11-10 |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: - ISSN: 1531-8257 ISO Abbreviation: - Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. |
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