| Serum insulin-like growth factor-I is negatively associated with serum adiponectin in type 2 diabetes mellitus. | |
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MedLine Citation:
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PMID: 21839662 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Although insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone-sulfate (DHEA-S) are involved in age-related diseases such as cardiovascular disease and diabetes mellitus, the association of these hormones with serum adiponectin level is still unclear. OBJECTIVE AND METHODS: To investigate the association between serum IGF-I and DHEA-S versus adiponectin, we conducted a cross-sectional study of 348 Japanese men with type 2 diabetes mellitus and examined their relationships. Serum total adiponectin level was measured by an ELISA kit. RESULTS: Simple correlation analysis showed that patients' age and duration of diabetes were negatively correlated with IGF-I and DHEA-S (p<0.01) and positively with adiponectin (p<0.01), while body mass index (BMI) was positively correlated with IGF-I and DHEA-S (p<0.001) and negatively with adiponectin (p<0.001). IGF-I was negatively correlated with adiponectin (r=-0.25, p<0.001) and DHEA-S was negatively correlated with adiponectin and HbA1c (r=-0.17, p=0.003 and r=-0.12, p=0.027, respectively). In multiple regression analysis adjusted for age, duration of diabetes, BMI, and serum creatinine, HbA1c was negatively associated with IGF-I and DHEA-S (β=-0.12, p=0.036 and β=-0.22, p<0.001, respectively). Adiponectin was negatively associated with IGF-I (β=-0.15, p=0.013), but not DHEA-S. Moreover, this association was still significant after additional adjustment for HbA1c (β=-0.18, p=0.005). CONCLUSIONS: Present cross-sectional study for the first time showed a negative association of serum IGF-I with serum adiponectin in Japanese men with type 2 diabetes independent of age, duration of diabetes, BMI, renal function, and HbA1c. |
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Authors:
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Ippei Kanazawa; Toru Yamaguchi; Toshitsugu Sugimoto |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-10 |
Journal Detail:
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Title: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society Volume: - ISSN: 1532-2238 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9814320 Medline TA: Growth Horm IGF Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ltd. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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