| Serum insulin concentration and arginine tolerance test in the cynomolgus monkey (Macaca fascicularis) | |
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MedLine Citation:
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PMID: 3284755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The standard value of serum insulin was determined to be less than 75 microU/ml with ninety-eight female adult cynomolgus monkeys of wild origin. Then, fifteen apparently healthy laboratory-bred female cynomolgus monkeys aged 6-8 years were studied to know the usefulness of the arginine tolerance test (ATT) by measuring blood glucose, insulin and glucagon. Prior to ATT, all animals had been diagnosed as non-diabetic by the intravenous glucose tolerance test (IVGTT). Arginine hydrochloride was infused intravenously at a dose of 0.5 g/kg. BW under anesthesia. According to the standard value of insulin, fifteen animals were divided into two groups, that is, the low (n = 7) and the high (n = 8) value groups. In the low value group, glucose and insulin value did not change significantly after arginine infusion and their responses were similar to those in the control group (saline infused, n = 4). But glucagon markedly increased from 10 to 45 minutes post infusion. In the high value group, glucagon response was similar to that in the low value group, while glucose and insulin values significantly decreased. It is concluded that the pancreatic alpha-cell function (glucagon secretion) can be judged by the ATT in the cynomolgus monkey but the beta-cell function (insulin secretion) can not be diagnosed. |
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Authors:
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T Sakurai; A Katsuta; T Yoshida |
Publication Detail:
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Type: English Abstract; Journal Article |
Journal Detail:
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Title: Jikken dobutsu. Experimental animals Volume: 37 ISSN: 0007-5124 ISO Abbreviation: Jikken Dobutsu Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-06-16 Completed Date: 1988-06-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1256412 Medline TA: Jikken Dobutsu Country: JAPAN |
Other Details:
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Languages: jpn Pagination: 53-8 Citation Subset: IM |
Affiliation:
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Tsukuba Primate Center for Medical Science, National Institute of Health, Ibaragi, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine / diagnostic use* Female Insulin / blood* Macaca / blood* Macaca fascicularis / blood* Pancreas / physiology* Pancreatic Function Tests |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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