| Serum insulin changes in arteriosclerotic breeder female rats versus non-arteriosclerotic virgin rats. | |
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MedLine Citation:
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PMID: 773805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunoreactive serum insulin (IRI), glucose, free fatty acids (FFA), and corticosterone (Cmpd. B) were measured in non-arteriosclerotic virgin versus arteriosclerotic, breeder female rats exhibiting normal 4-day cycles. In the arteriosclerotic breeder females, the normal increase in IRI during proestrus and estrus did not occur. The IRI levels during these times were comparable to the minimal levels found during metestrus in the non-arteriosclerotic virgin rats and were even lower than the IRI levels or ovariectomized rats. Since both young and old non-arteriosclerotic virgin rats had similar IRI patterns, the lack of cyclic insulin change in the arteriosclerotic breeder rats is not considered to be age-related. Instead, these changes are ascribed to hypothalamic-pituitary-adrenal hyperactivity associated with repeated reproductive activity and the development of arteriosclerosis. |
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Authors:
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B K Lewis; B C Wexler |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hormone research Volume: 6 ISSN: 0301-0163 ISO Abbreviation: Horm. Res. Publication Date: 1975 |
Date Detail:
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Created Date: 1976-08-02 Completed Date: 1976-08-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0366126 Medline TA: Horm Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 247-57 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteriosclerosis / blood* Blood Glucose / blood Body Weight Castration Corticosterone / blood Estrus Fatty Acids, Nonesterified / blood Female Insulin / blood*, metabolism Islets of Langerhans / metabolism, ultrastructure Parity Pregnancy Pregnancy, Animal* Rats |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fatty Acids, Nonesterified; 11061-68-0/Insulin; 50-22-6/Corticosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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