| Serum inhibin B correlates with successful ovulation in infertile women. | |
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MedLine Citation:
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PMID: 12877256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate whether inhibin B and activin A serum and follicular fluid levels in infertile women undergoing induction of superovulation correlate with successful ovulation. METHODS: Infertile women (n = 16) (30-43 years of age) undergoing induction of superovulation for assisted reproduction were studied. A blood sample was collected before and days 3, 8, and 12 during the induction of superovulation. A follicular fluid sample at the time of ovarian pick up was also collected. Serum and follicular fluid were assayed for inhibin B, activin A, and estradiol. RESULTS: According to the successful follicular development women were divided in two groups: (A) responders (n = 10) and (B) poor responders (n = 6). Women of group A showed mean follicular fluid inhibin B levels higher than in group B (P = 0.001), while no significant difference for activin A levels was found. During induction of superovulation serum activin A levels did not change in both groups of women, while inhibin B and estradiol levels significantly increase only in responder women (P < 0.001). Serum inhibin B and estradiol levels correlated with follicles developed > or = 10 mm (P = 0.000). CONCLUSIONS: Serum inhibin B is an effective marker of follicular development in infertile women undergoing induction of superovulation, and may represent a further marker for ovarian follicular capacity. |
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Authors:
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S Luisi; M Palumbo; G Calonaci; V De Leo; S Razzi; P Inaudi; G Cobellis; F Petraglia |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of assisted reproduction and genetics Volume: 20 ISSN: 1058-0468 ISO Abbreviation: J. Assist. Reprod. Genet. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-07-24 Completed Date: 2004-03-30 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 9206495 Medline TA: J Assist Reprod Genet Country: United States |
Other Details:
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Languages: eng Pagination: 241-7 Citation Subset: IM |
Affiliation:
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Department of Pediatric, Obstetric and Reproductive Medicine, Chair of Obstetric and Gynecology, University of Siena, 53100 Siena, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activins
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analysis,
blood Biological Markers / blood Estradiol / blood Female Fertilization in Vitro / methods* Follicular Fluid / chemistry Humans Infertility, Female / blood* Inhibin-beta Subunits / analysis, blood Inhibins / analysis, blood* Ovulation Induction / methods* Pregnancy Pregnancy Outcome |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/activin A; 0/inhibin B; 104625-48-1/Activins; 50-28-2/Estradiol; 57285-09-3/Inhibins; 93443-12-0/Inhibin-beta Subunits |
| Comments/Corrections | |
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